MicroRNA-181b Serves as a Circulating Biomarker and Regulates Inflammation in Heart Failure.
Journal
Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
04
2021
revised:
10
06
2021
accepted:
16
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
15
1
2022
Statut:
epublish
Résumé
Heart failure (HF) is the typical terminal stage of cardiac diseases involving inflammatory states. The function of microRNAs (miRNAs) in the progress of HF remains poorly understood. In this study, real-time PCR results showed a decreased expression of miRNA-181b (miR-181b) in HF patients compared with healthy individuals. Besides, miR-181b expressions were negatively correlated with hypersensitive C-reactive protein (hsCRP) levels in the serum of HF patients. Receiver operator characteristic (ROC) curve analysis showed that miR-181b was a diagnostic predictor of HF, and the area under the curve was 0.970 (DCM-induced HF group) and 0.962 (ICM-induced HF group). Strikingly, in HF rats induced by isoproterenol (ISO), the expression of miR-181b of heart tissue was suppressed before tumor necrosis factor-alpha (TNF-
Identifiants
pubmed: 34306253
doi: 10.1155/2021/4572282
pmc: PMC8270725
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Inflammation Mediators
0
MIrn181 microRNA, human
0
MicroRNAs
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
4572282Informations de copyright
Copyright © 2021 Hongxiao Yang et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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