The Assessment of Pentraxin 3: A Novel Biomarker in Early Detection of Infection in Newborns.
Adult
Biomarkers
/ blood
C-Reactive Protein
/ metabolism
Case-Control Studies
Early Diagnosis
Female
Fetal Blood
/ metabolism
Humans
Infant, Newborn
Infant, Newborn, Diseases
/ blood
Infections
/ blood
Male
Procalcitonin
/ blood
ROC Curve
Serum Amyloid P-Component
/ metabolism
Statistics, Nonparametric
Young Adult
Journal
BioMed research international
ISSN: 2314-6141
Titre abrégé: Biomed Res Int
Pays: United States
ID NLM: 101600173
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
12
2020
revised:
29
04
2021
accepted:
23
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
23
9
2021
Statut:
epublish
Résumé
As the clinical manifestation of neonatal infection is nonspecific and characterised by varied clinical features, it is highly problematic to establish an early diagnosis. Recently, hopes have been raised by the new acute-phase protein-pentraxin 3 (PTX3). PTX3 belongs to the family of long pentraxins, which is synthesized in numerous cells like endothelial cells, macrophages, and monocytes infiltrating sites of inflammation. There were statistically significant differences in PTX3 levels between healthy and sick newborns both in the umbilical cord ( Serum PTX3 is an important and specific biomarker of early infection. It is already elevated in the umbilical cord, so measuring PTX3 concentration might be useful in the early prediction of infection in newborns.
Identifiants
pubmed: 34307663
doi: 10.1155/2021/6638622
pmc: PMC8266451
doi:
Substances chimiques
Biomarkers
0
Procalcitonin
0
Serum Amyloid P-Component
0
PTX3 protein
148591-49-5
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6638622Informations de copyright
Copyright © 2021 Małgorzata Baumert et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this paper.
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