The power and the promise of circRNAs for cancer precision medicine with functional diagnostics and prognostic prediction.

Carcinogenesis / genetics Exons Humans Introns Neoplasm Invasiveness Neoplasm Metastasis Neoplasms / diagnosis Nucleic Acid Conformation Precision Medicine Prognosis RNA, Circular / chemistry

Journal

Carcinogenesis
ISSN: 1460-2180
Titre abrégé: Carcinogenesis
Pays: England
ID NLM: 8008055

Informations de publication

Date de publication:
12 11 2021
Historique:
received: 07 06 2021
revised: 17 07 2021
accepted: 26 07 2021
pubmed: 28 7 2021
medline: 31 12 2021
entrez: 27 7 2021
Statut: ppublish

Résumé

Circular RNA (circRNA) is a large class of covalently closed circRNA. As a member of competitive endogenous RNA, it participates in the regulation of circRNA-miRNA-mRNA network and plays an important role in the regulation of physiology and pathology. CircRNA is produced by the reverse splicing of exon, intron or both, forming exon or intron circRNA. Studies have shown that circRNA is a ubiquitous molecule, which exceeds the linear mRNA distributed in human cells. Because of its covalent closed-loop structure, circRNA is resistant to RNase R, which is more stable than linear mRNA; circRNA is highly conserved in different species. It was found that circRNA competitively adsorbs miRNA, as a miRNA sponge, to involve in the expression regulation of a variety of genes and plays an important role in tumor development, invasion, metastasis and other processes. These molecules offer new potential opportunities for therapeutic intervention and serve as biomarkers for diagnosis. In this paper, the origin, characteristics and functions of circRNA and its role in tumor development, invasion and metastasis, diagnosis and prognosis are reviewed.

Identifiants

DOI: 10.1093/carcin/bgab071 PMID: 34313732
pubmed: 34313732
pii: 6329137
doi: 10.1093/carcin/bgab071
doi:

Substances chimiques

RNA, Circular 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1305-1313

Subventions

Organisme : National Natural Science Foundation of China
ID : 81772932
Organisme : Key program of Hunan Provincial Department of science and technology
ID : 2020WK2020
Organisme : Shanghai Committee of Science and Technology
ID : 21140903500
Organisme : Shanghai Natural Science Foundation
ID : 20ZR1472400
Organisme : Construction of Clinical Medical Centre for Tumor Biological Samples in Nantong
ID : HS2016004
Organisme : Science and Technology Project of Nantong
ID : JC2018010
Organisme : Jiangsu Provincial University Natural Science Funding
ID : 19KJB180021

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Auteurs

Yu-Shui Ma (YS)

National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.
Department of Tumor, Affiliated Tumor Hospital of Nantong University, Nantong, China.
International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital/Institute, National Center for Liver Cancer, the Second Military Medical University, Shanghai, China.
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Yong-Feng Cao (YF)

Department of Tumor, Affiliated Tumor Hospital of Nantong University, Nantong, China.

Ji-Bin Liu (JB)

Department of Tumor, Affiliated Tumor Hospital of Nantong University, Nantong, China.

Wen Li (W)

National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.

Jing Deng (J)

National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.

Xiao-Li Yang (XL)

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Rui Xin (R)

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Yi Shi (Y)

National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.
Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Dan-Dan Zhang (DD)

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Zhong-Wei Lv (ZW)

Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.

Da Fu (D)

National Engineering Laboratory for Deep Process of Rice and Byproducts, College of Food Science and Engineering, Central South University of Forestry and Technology, Changsha, Hunan, China.
Institute of Pancreatic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
ORCID: 0000-0002-0878-2575

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Carcinogenèse › The power and the promise of circRNAs for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Exons › The power and the promise of circRNAs for...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The power and the promise of circRNAs for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Introns › The power and the promise of circRNAs for...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › The power and the promise of circRNAs for...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › The power and the promise of circRNAs for...
questionsmedicales.fr › Tumeurs › The power and the promise of circRNAs for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › The power and the promise of circRNAs for...
questionsmedicales.fr › Professions de santé › Médecine › Médecine clinique › Médecine de précision › The power and the promise of circRNAs for...
questionsmedicales.fr › Diagnostic › Pronostic › The power and the promise of circRNAs for...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN circulaire › The power and the promise of circRNAs for...