Comprehensive Breast Cancer Risk Assessment for

Breast cancer risks for This study included deidentified clinical records from 358,095 women of European ancestry who received testing with a multigene panel (September 2013 to November 2019). Model development included ORs for association of PV status with breast cancer were 2.01 (95% CI, 1.88 to 2.16) and 1.83 (95% CI, 1.68 to 2.00) for In

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© 2021 by American Society of Clinical Oncology.

Déclaration de conflit d'intérêts

Shannon Gallagher Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Elisha Hughes Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Allison W. Kurian Research Funding: Myriad Genetics Other Relationship: Ambry Genetics, Color Genomics, GeneDx/BioReference, InVitae, Genentech Susan M. Domchek Honoraria: AstraZeneca, Clovis Oncology, Bristol Myers Squibb Research Funding: AstraZeneca, Clovis Oncology Open Payments Link: https://openpaymentsdata.cms.gov/physician/917904 Judy Garber Consulting or Advisory Role: Novartis, GTx, Helix BioPharma, Konica Minolta, Aleta BioTherapeutics, H3 Biomedicine, Kronos Bio Research Funding: Novartis, Ambry Genetics, InVitae, Myriad Genetics Other Relationship: Susan G. Komen for the Cure, AACR, Diana Helis Henry Medical Foundation, James P. Wilmot Foundation, Adrienne Helis Malvin Medical Research Foundation, Breast Cancer Research Foundation, Facing Our Risk of Cancer Empowered Braden Probst Employment: Myriad Genetics Brian Morris Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Placede Tshiaba Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Stephanie Meek Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Eric Rosenthal Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Benjamin Roa Employment: Myriad Genetics Leadership: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Research Funding: Myriad Genetics Patents, Royalties, Other Intellectual Property: Intellectual Property held by employer Myriad Genetics Travel, Accommodations, Expenses: Myriad Genetics Thomas P. Slavin Employment: Myriad Genetics Leadership: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Susanne Wagner Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Patents, Royalties, Other Intellectual Property: Co-author of patents held by Myriad Genetics, no royalties Jeffrey Weitzel Speakers' Bureau: AstraZeneca Alexander Gutin Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics, Gilead Sciences Jerry S. Lanchbury Employment: Myriad Genetics Leadership: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Patents, Royalties, Other Intellectual Property: I am an inventor on Multiple patents filed by Myriad Genetics Travel, Accommodations, Expenses: Myriad Genetics Mark Robson Consulting or Advisory Role: Change HealthCare Research Funding: AstraZeneca, Pfizer, Merck Other Relationship: Research to Practice, Clinical Care Options, Physicans' Education Resource, Invitae, Pfizer Uncompensated Relationships: Merck, Pfizer, Daiichi Sankyo, Epic Sciences Open Payments Link: https://openpaymentsdata.cms.gov/physician/612669/summary No other potential conflicts of interest were reported.Shannon Gallagher Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Elisha Hughes Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Allison W. Kurian Research Funding: Myriad Genetics Other Relationship: Ambry Genetics, Color Genomics, GeneDx/BioReference, InVitae, Genentech Susan M. Domchek Honoraria: AstraZeneca, Clovis Oncology, Bristol Myers Squibb Research Funding: AstraZeneca, Clovis Oncology Open Payments Link: https://openpaymentsdata.cms.gov/physician/917904 Judy Garber Consulting or Advisory Role: Novartis, GTx, Helix BioPharma, Konica Minolta, Aleta BioTherapeutics, H3 Biomedicine, Kronos Bio Research Funding: Novartis, Ambry Genetics, InVitae, Myriad Genetics Other Relationship: Susan G. Komen for the Cure, AACR, Diana Helis Henry Medical Foundation, James P. Wilmot Foundation, Adrienne Helis Malvin Medical Research Foundation, Breast Cancer Research Foundation, Facing Our Risk of Cancer Empowered Braden Probst Employment: Myriad Genetics Brian Morris Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Placede Tshiaba Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Stephanie Meek Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Eric Rosenthal Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Benjamin Roa Employment: Myriad Genetics Leadership: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Research Funding: Myriad Genetics Patents, Royalties, Other Intellectual Property: Intellectual Property held by employer Myriad Genetics Travel, Accommodations, Expenses: Myriad Genetics Thomas P. Slavin Employment: Myriad Genetics Leadership: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Susanne Wagner Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Patents, Royalties, Other Intellectual Property: Co-author of patents held by Myriad Genetics, no royalties Jeffrey Weitzel Speakers' Bureau: AstraZeneca Alexander Gutin Employment: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics, Gilead Sciences Jerry S. Lanchbury Employment: Myriad Genetics Leadership: Myriad Genetics Stock and Other Ownership Interests: Myriad Genetics Patents, Royalties, Other Intellectual Property: I am an inventor on Multiple patents filed by Myriad Genetics Travel, Accommodations, Expenses: Myriad Genetics Mark Robson Consulting or Advisory Role: Change HealthCare Research Funding: AstraZeneca, Pfizer, Merck Other Relationship: Research to Practice, Clinical Care Options, Physicans' Education Resource, Invitae, Pfizer Uncompensated Relationships: Merck, Pfizer, Daiichi Sankyo, Epic Sciences Open Payments Link: https://openpaymentsdata.cms.gov/physician/612669/summary No other potential conflicts of interest were reported.