Low Dietary Fiber Intake Links Development of Obesity and Lupus Pathogenesis.
Adaptive Immunity
Adipose Tissue, White
/ immunology
Adiposity
Adolescent
Adult
Aged
Aged, 80 and over
Animal Feed
Animals
Autoantibodies
/ blood
Autoimmunity
Case-Control Studies
Dietary Fiber
/ administration & dosage
Disease Models, Animal
Disease Progression
Energy Metabolism
Female
Humans
Inflammation Mediators
/ metabolism
Intestinal Mucosa
/ immunology
Lupus Erythematosus, Systemic
/ etiology
Male
Mice, Inbred NZB
Middle Aged
Nutritive Value
Obesity
/ etiology
Permeability
Young Adult
SCFA
SLE
autoimmunity
diet
fiber
lupus
obesity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
04
2021
accepted:
23
06
2021
entrez:
2
8
2021
pubmed:
3
8
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Changed dietary habits in Western countries such as reduced fiber intake represent an important lifestyle factor contributing to the increase in inflammatory immune-mediated diseases. The mode of action of beneficial fiber effects is not fully elucidated, but short-chain fatty acids (SCFA) and gut microbiota have been implicated. The aim of this study was to explore the impact of dietary fiber on lupus pathology and to understand underlying mechanisms. Here, we show that in lupus-prone NZB/WF1 mice low fiber intake deteriorates disease progression reflected in accelerated mortality, autoantibody production and immune dysregulation. In contrast to our original assumption, microbiota suppression by antibiotics or direct SCFA feeding did not influence the course of lupus-like disease. Mechanistically, our data rather indicate that in low fiber-fed mice, an increase in white adipose tissue mass, fat-inflammation and a disrupted intestinal homeostasis go along with systemic, low-grade inflammation driving autoimmunity. The links between obesity, intestinal leakage and low-grade inflammation were confirmed in human samples, while adaptive immune activation predominantly correlated with lupus activity. We further propose that an accelerated gastro-intestinal passage along with energy dilution underlies fiber-mediated weight regulation. Thus, our data highlight the often-overlooked effects of dietary fiber on energy homeostasis and obesity prevention. Further, they provide insight into how intricately the pathologies of inflammatory immune-mediated conditions, such as obesity and autoimmunity, might be interlinked, possibly sharing common pathways.
Identifiants
pubmed: 34335609
doi: 10.3389/fimmu.2021.696810
pmc: PMC8320762
doi:
Substances chimiques
Autoantibodies
0
Dietary Fiber
0
Inflammation Mediators
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
696810Informations de copyright
Copyright © 2021 Schäfer, Eichhorst, Hentze, Kraemer, Amend, Sprenger, Fluhr, Finzel, Daniel, Salzer, Rizzi, Voll and Chevalier.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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