Monocyte perturbation modulates the ovarian response to an immune challenge.
Cx3cr1-Dtr rat
Inflammation
Lipopolysaccharide (LPS)
Luteinising hormone (LH)
Macrophage
Ovarian follicle
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
03
06
2021
revised:
27
07
2021
accepted:
29
07
2021
pubmed:
3
8
2021
medline:
21
1
2022
entrez:
2
8
2021
Statut:
ppublish
Résumé
Our recent findings indicate that an acute depletion of monocytes has no sustained effects on ovarian follicle health. Here, we utilised a Cx3cr1-Dtr transgenic Wistar rat model to transiently deplete monocytes and investigated the impact of an acute immune challenge by lipopolysaccharide (LPS) on ovarian follicle health and ovulatory capacity relative to wt once the monocytes had repopulated. Monocyte depletion and repopulation exacerbated the effects of LPS in several domains. As such, monocyte perturbation decreased the numbers of secondary follicles in those challenged with LPS. Monocyte perturbation was also associated with reduced antral follicle numbers and circulating luteinising hormone (LH) levels, as well as potential changes in ovarian sensitivity to LH, exacerbated by LPS. These data suggest that monocyte depletion and repopulation induce a transient suppression of ovulatory capacity in response to a subsequent immune challenge, but this is likely to be restored once the pro-inflammatory environment is resolved.
Identifiants
pubmed: 34339824
pii: S0303-7207(21)00262-8
doi: 10.1016/j.mce.2021.111418
pii:
doi:
Substances chimiques
CX3C Chemokine Receptor 1
0
CX3CR1 protein, rat
0
Heparin-binding EGF-like Growth Factor
0
Lipopolysaccharides
0
Luteinizing Hormone
9002-67-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111418Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.