Total Content of Piperidine Analysis in Artane by RP-HPLC Using Pre-Column Derivatization with 4-Toluene Sulfonyl Chloride.

Chromatography, High Pressure Liquid / methods Piperidines Sulfinic Acids Tosyl Compounds Trihexyphenidyl

Journal

Journal of chromatographic science
ISSN: 1945-239X
Titre abrégé: J Chromatogr Sci
Pays: United States
ID NLM: 0173225

Informations de publication

Date de publication:
03 Sep 2022
Historique:
received: 02 04 2021
revised: 24 06 2021
accepted: 11 07 2021
pubmed: 4 8 2021
medline: 8 9 2022
entrez: 3 8 2021
Statut: ppublish

Résumé

A simple, sensitive and accurate reversed-phase high-performance liquid chromatography (RP-HPLC) method was established for the determination of piperidine and piperidine hydrochloride in artane, using pre-column derivatization with 4-toluenesulfonyl chloride. The RP-HPLC method was carried out on a Inertsil C18 column (250 × 4.6 mm I.D.) maintained at 30°C. The mobile phase consisted of water with 0.1% phosphoric acid (phase A) and acetonitrile (phase B) (32:68, V:V) at a flow rate of 1.0 mL/min. Linearity of piperidine was found in the range of 0.44-53.33 μg/mL with R2 = 0.9996. The limit of detection was estimated to be 0.15 μg/mL, and the limit of quantitation was 0.44 μg/mL. The average recovery was 101.82% with relative standard deviations of 0.6% at three spiked levels. The developed method using HPLC-ultraviolet system was a rapid tool for routine analysis of piperidine in the bulk form with good accuracy.

Identifiants

DOI: 10.1093/chromsci/bmab099 PMID: 34343261
pubmed: 34343261
pii: 6337891
doi: 10.1093/chromsci/bmab099
doi:

Substances chimiques

Piperidines 0
Sulfinic Acids 0
Tosyl Compounds 0
4-toluenesulfonyl chloride 027KYN78B4
Trihexyphenidyl 6RC5V8B7PO
sulfonyl chloride 7791-25-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

613-619

Subventions

Organisme : National Natural Science Foundation of China
ID : 21804040
Organisme : Natural Science Foundation of Hunan Province
ID : 2019JJ50134
Organisme : State Key Laboratory of Chemo/Biosensing and Chemometrics
ID : 2018015

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Auteurs

Guiyin Zhou (G)

Hunan Key Lab of Biomedical Materials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, China.

Yao Chen (Y)

Hunan Key Lab of Biomedical Materials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, China.

Ying Tang (Y)

Hunan Key Lab of Biomedical Materials and Devices, College of Life Sciences and Chemistry, Hunan University of Technology, Zhuzhou 412008, China.
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
ORCID: 0000-0001-8512-5942

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › Total Content of Piperidine Analysis in Artane...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Total Content of Piperidine Analysis in Artane...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Acides du soufre › Acides sulfiniques › Total Content of Piperidine Analysis in Artane...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Composés tosyliques › Total Content of Piperidine Analysis in Artane...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pipéridines › Trihexyphénidyle › Total Content of Piperidine Analysis in Artane...