Association between HLA genotypes and COVID-19 susceptibility, severity and progression: a comprehensive review of the literature.
COVID-19
Genotypes
HLA
Haplotypes
MHC
Polymorphisms
SARS-CoV-2
Journal
European journal of medical research
ISSN: 2047-783X
Titre abrégé: Eur J Med Res
Pays: England
ID NLM: 9517857
Informations de publication
Date de publication:
03 Aug 2021
03 Aug 2021
Historique:
received:
21
05
2021
accepted:
27
07
2021
entrez:
4
8
2021
pubmed:
5
8
2021
medline:
10
8
2021
Statut:
epublish
Résumé
The COVID-19 pandemic has markedly impacted on cultural, political, and economic structures all over the world. Several aspects of its pathogenesis and related clinical consequences have not yet been elucidated. Infection rates, as well morbidity and mortality differed within countries. It is intriguing for scientists to understand how patient genetics may influence the outcome of the condition, to clarify which aspects could be related the clinical variability of SARS-CoV-2 disease. We reviewed the studies exploring the role of human leukocyte antigens (HLA) genotypes on individual responses to SARS-CoV-2 infection and/or progression, discussing also the contribution of the immunological patterns MHC-related. In March 2021, the main online databases were accessed. All the articles that investigated the possible association between the HLA genotypes and related polymorphisms with susceptibility, severity and progression of COVID-19 were considered. Although both genetic and environmental factors are certainly expected to influence the susceptibility to or protection of individuals, the HLA and related polymorphisms can influence susceptibility, progression and severity of SARS-CoV-2 infection. The crucial role played by HLA molecules in the immune response, especially through pathogen-derived peptide presentation, and the huge molecular variability of HLA alleles in the human populations could be responsible for the different rates of infection and the different patients following COVID-19 infection.
Identifiants
pubmed: 34344463
doi: 10.1186/s40001-021-00563-1
pii: 10.1186/s40001-021-00563-1
pmc: PMC8329616
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
84Informations de copyright
© 2021. The Author(s).
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