Granzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver.

Animals Antigens, CD / metabolism GPI-Linked Proteins / metabolism Granzymes / metabolism Immunity, Innate / immunology Liver / cytology Lymphocyte Subsets / cytology Lymphocytes / cytology Mice Receptors, Immunologic / metabolism
CD160 Nfil3 granzyme A innate lymphoid cells natural killer

Journal

European journal of immunology
ISSN: 1521-4141
Titre abrégé: Eur J Immunol
Pays: Germany
ID NLM: 1273201

Informations de publication

Date de publication:
11 2021
Historique:
revised: 23 06 2021
received: 03 02 2021
accepted: 30 07 2021
pubmed: 5 8 2021
medline: 17 12 2021
entrez: 4 8 2021
Statut: ppublish

Résumé

Type 1 innate lymphoid cells (ILC1) are tissue-resident lymphocytes that provide early protection against bacterial and viral infections. Discrete transcriptional states of ILC1 have been identified in homeostatic and pathological contexts. However, whether these states delineate ILC1 with different functional properties is not completely understood. Here, we show that liver ILC1 are heterogeneous for the expression of distinct effector molecules and surface receptors, including granzyme A (GzmA) and CD160, in mice. ILC1 expressing high levels of GzmA are enriched in the liver of adult mice, and represent the main hepatic ILC1 population at birth. However, the heterogeneity of GzmA and CD160 expression in hepatic ILC1 begins perinatally and increases with age. GzmA

Identifiants

DOI: 10.1002/eji.202149209 PMID: 34347289 PMC: PMC9292164
pubmed: 34347289
doi: 10.1002/eji.202149209
pmc: PMC9292164
doi:

Substances chimiques

Antigens, CD 0
Cd160 protein, mouse 0
GPI-Linked Proteins 0
Receptors, Immunologic 0
Granzymes EC 3.4.21.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2568-2575

Subventions

Organisme : CIHR
ID : PG388232
Pays : Canada

Informations de copyright

© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

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Auteurs

Chiara Di Censo (C)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Marie Marotel (M)

Ottawa Hospital Research Institute, Cancer Therapeutics Program, Ottawa, Ontario, Canada.
Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Irene Mattiola (I)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, Berlin, Germany.
Deutsches Rheuma-Forschungszentrum, Mucosal and Developmental Immunology, Berlin, Germany.

Lena Müller (L)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Gianluca Scarno (G)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Giuseppe Pietropaolo (G)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Giovanna Peruzzi (G)

Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia, Rome, Italy.

Mattia Laffranchi (M)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Julija Mazej (J)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Mohamed Shaad Hasim (MS)

Ottawa Hospital Research Institute, Cancer Therapeutics Program, Ottawa, Ontario, Canada.
Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Sara Asif (S)

Ottawa Hospital Research Institute, Cancer Therapeutics Program, Ottawa, Ontario, Canada.
Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Eleonora Russo (E)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Luana Tomaipitinca (L)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Helena Stabile (H)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Seung-Hwan Lee (SH)

Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Laura Vian (L)

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Massimo Gadina (M)

Translational Immunology Section, Office of Science and Technology, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
ORCID: 0000-0001-9084-6736

Angela Gismondi (A)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Han-Yu Shih (HY)

Neuro-Immune Regulome Unit, National Eye Institute and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.

Yohei Mikami (Y)

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.

Cristina Capuano (C)

Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Giovanni Bernardini (G)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.

Michael Bonelli (M)

Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Silvano Sozzani (S)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.

Andreas Diefenbach (A)

Laboratory of Innate Immunity, Department of Microbiology, Infectious Diseases and Immunology, Campus Benjamin Franklin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Berlin Institute of Health (BIH), Anna-Louisa-Karsch Strasse 2, Berlin, Germany.
Deutsches Rheuma-Forschungszentrum, Mucosal and Developmental Immunology, Berlin, Germany.
ORCID: 0000-0002-9176-9530

Michele Ardolino (M)

Ottawa Hospital Research Institute, Cancer Therapeutics Program, Ottawa, Ontario, Canada.
Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.

Angela Santoni (A)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
IRCCS Neuromed, Pozzilli, Italy.

Giuseppe Sciumè (G)

Department of Molecular Medicine, Sapienza University of Rome, Laboratory affiliated to Istituto Pasteur Italia - Fondazione Cenci Bolognetti, Rome, Italy.
ORCID: 0000-0003-0131-512X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Protéines liées au GPI › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Système digestif › Foie › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Sous-populations de lymphocytes › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Granzyme A and CD160 expression delineates...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Granzyme A and CD160 expression delineates...