Beyond the gene: epigenetic and cis-regulatory targets offer new breeding potential for the future.
Journal
Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
received:
15
06
2021
accepted:
06
07
2021
pubmed:
5
8
2021
medline:
8
4
2022
entrez:
4
8
2021
Statut:
ppublish
Résumé
For millennia, natural and artificial selection has combined favourable alleles for desirable traits in crop species. While modern plant breeding has achieved steady increases in crop yields over the last century, on the current trajectory we will simply not meet demand by 2045. Novel breeding strategies and sources of genetic variation will be required to sustainably fill predicted yield gaps and meet new consumer preferences. Here, we highlight that stepping up to meet this grand challenge will increasingly require thinking 'beyond the gene'. Significant progress has been made in understanding the contributions of both epigenetic variation and cis-regulatory variation to plant traits. This non-genic variation has great potential in future breeding, synthetic biology and biotechnology applications.
Identifiants
pubmed: 34348216
pii: S0958-1669(21)00120-8
doi: 10.1016/j.copbio.2021.07.008
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
88-94Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P013511/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.