Vertically transferred maternal immune cells promote neonatal immunity against early life infections.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
04 08 2021
04 08 2021
Historique:
received:
11
06
2020
accepted:
26
06
2021
entrez:
5
8
2021
pubmed:
6
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
During mammalian pregnancy, immune cells are vertically transferred from mother to fetus. The functional role of these maternal microchimeric cells (MMc) in the offspring is mostly unknown. Here we show a mouse model in which MMc numbers are either normal or low, which enables functional assessment of MMc. We report a functional role of MMc in promoting fetal immune development. MMc induces preferential differentiation of hematopoietic stem cells in fetal bone marrow towards monocytes within the myeloid compartment. Neonatal mice with higher numbers of MMc and monocytes show enhanced resilience against cytomegalovirus infection. Similarly, higher numbers of MMc in human cord blood are linked to a lower number of respiratory infections during the first year of life. Our data highlight the importance of MMc in promoting fetal immune development, potentially averting the threats caused by early life exposure to pathogens.
Identifiants
pubmed: 34349112
doi: 10.1038/s41467-021-24719-z
pii: 10.1038/s41467-021-24719-z
pmc: PMC8338998
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4706Informations de copyright
© 2021. The Author(s).
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