MR1 encompasses at least six allele groups with coding region alterations.
MHC class I-related
MHC-I like
MR1 protein
histocompatibility antigens class I
immunotherapy
Journal
HLA
ISSN: 2059-2310
Titre abrégé: HLA
Pays: England
ID NLM: 101675570
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
29
06
2021
received:
23
03
2021
accepted:
30
07
2021
pubmed:
6
8
2021
medline:
29
4
2022
entrez:
5
8
2021
Statut:
ppublish
Résumé
Unlike classical HLA class I genes, MR1 is assumed to have limited polymorphic positions. We developed a MR1 specific PCR assay and sequenced 56 DNA samples from cells with a diverse set of HLA genotypes. In this relatively small panel we found six allele groups encoding for different MR1 proteins. The two most frequent allele groups found in this panel had a frequency of 71% (MR1*01) and 25% (MR1*02), respectively. Moreover, the panel contained many intronic SNPs and silent variants, with individual samples containing up to 15 heterozygous positions. The data presented here is consistent with marked variation in MR1.
Substances chimiques
Histocompatibility Antigens Class I
0
MR1 protein, human
0
Minor Histocompatibility Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
509-516Informations de copyright
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
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