Mesenchymal stem cells from biology to therapy.
cell therapy
extracellular vesicle
mesenchymal stem cell
mesenchymal stromal cells
regenerative medicine
tissue engineering
Journal
Emerging topics in life sciences
ISSN: 2397-8554
Titre abrégé: Emerg Top Life Sci
Pays: England
ID NLM: 101706399
Informations de publication
Date de publication:
29 10 2021
29 10 2021
Historique:
received:
05
03
2021
revised:
30
05
2021
accepted:
21
07
2021
pubmed:
7
8
2021
medline:
15
3
2022
entrez:
6
8
2021
Statut:
ppublish
Résumé
Mesenchymal stem cells are as fascinating as they are enigmatic. They appear capable of performing a wide array of functions that cross skeletal biology, immunology and haematology. As therapeutics, mesenchymal stem cells or even just their secreted products may be used to regenerate tissue lost through injury or disease and suppress damaging immune reactions. However, these cells lack unique markers and are hard to identify and isolate as pure cell populations. They are often grown in laboratories using basic and undefined culture conditions. We cannot even agree on their name. While mesenchymal stem cells may lack the developmental understanding and defined differentiation hierarchies of their more illustrious stem cell cousins, they offer a compelling scientific challenge. In depth understanding of mesenchymal stem cell biology will enable us to exploit fully one of the most clinically valuable cell sources.
Identifiants
pubmed: 34355761
pii: 229484
doi: 10.1042/ETLS20200303
pmc: PMC8639183
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
539-548Subventions
Organisme : Wellcome Trust
ID : 204829
Pays : United Kingdom
Informations de copyright
© 2021 The Author(s).
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