Betulin, a Newly Characterized Compound in
Acacia
/ chemistry
Antineoplastic Agents, Phytogenic
/ chemistry
Apoptosis
/ drug effects
Binding Sites
Casein Kinase 1 epsilon
/ antagonists & inhibitors
Cell Proliferation
/ drug effects
Fusion Proteins, bcr-abl
/ antagonists & inhibitors
Gene Expression Regulation, Leukemic
/ drug effects
Glycogen Synthase Kinase 3
/ antagonists & inhibitors
Humans
Janus Kinase 3
/ antagonists & inhibitors
K562 Cells
Mitogen-Activated Protein Kinase 1
/ antagonists & inhibitors
Mitogen-Activated Protein Kinase 3
/ antagonists & inhibitors
Models, Molecular
NIMA-Related Kinases
/ antagonists & inhibitors
Plant Bark
/ chemistry
Plant Extracts
/ chemistry
Protein Binding
Protein Conformation
Protein Kinase Inhibitors
/ chemistry
Proto-Oncogene Proteins c-abl
/ antagonists & inhibitors
Signal Transduction
Triterpenes
/ chemistry
Vascular Endothelial Growth Factor Receptor-2
/ antagonists & inhibitors
Acacia stem bark
polypharmacology
protein kinase inhibitors
triterpenoids
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
29 Jul 2021
29 Jul 2021
Historique:
received:
02
06
2021
revised:
26
07
2021
accepted:
27
07
2021
entrez:
7
8
2021
pubmed:
8
8
2021
medline:
15
9
2021
Statut:
epublish
Résumé
The purpose of this work is to investigate the protein kinase inhibitory activity of constituents from
Identifiants
pubmed: 34361750
pii: molecules26154599
doi: 10.3390/molecules26154599
pmc: PMC8347092
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
BCR-ABL1 fusion protein, human
0
Plant Extracts
0
Protein Kinase Inhibitors
0
Triterpenes
0
betulin
6W70HN7X7O
KDR protein, human
EC 2.7.10.1
Vascular Endothelial Growth Factor Receptor-2
EC 2.7.10.1
ABL1 protein, human
EC 2.7.10.2
Fusion Proteins, bcr-abl
EC 2.7.10.2
JAK3 protein, human
EC 2.7.10.2
Janus Kinase 3
EC 2.7.10.2
Proto-Oncogene Proteins c-abl
EC 2.7.10.2
Casein Kinase 1 epsilon
EC 2.7.11.1
NEK6 protein, human
EC 2.7.11.1
NIMA-Related Kinases
EC 2.7.11.1
MAPK1 protein, human
EC 2.7.11.24
MAPK3 protein, human
EC 2.7.11.24
Mitogen-Activated Protein Kinase 1
EC 2.7.11.24
Mitogen-Activated Protein Kinase 3
EC 2.7.11.24
Glycogen Synthase Kinase 3
EC 2.7.11.26
glycogen synthase kinase 3 alpha
EC 2.7.11.26
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Tertiary Education Trust Fund
ID : TETFund/Sep2018
Organisme : Association Nationale de la Recherche et de la Technologie
ID : Cifre#2019/0686
Organisme : Fondation d'Entreprise Grand Ouest (BPGO)
ID : Houarnine
Organisme : Agence Nationale de la Recherche
ID : Investissements d'Avenir program via the OCEANOMICs project, grant #ANR-11-BTBR-0008
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