Neutrophil Extracellular Traps in Fatal COVID-19-Associated Lung Injury.
Aged
Aged, 80 and over
Antigens, CD
/ metabolism
Autopsy
COVID-19
/ pathology
Cell Adhesion Molecules
/ metabolism
Extracellular Traps
/ virology
Female
GPI-Linked Proteins
/ metabolism
Humans
Immunohistochemistry
Lung
/ pathology
Lung Injury
/ pathology
Male
Neutrophils
/ metabolism
Peroxidase
/ metabolism
Journal
Disease markers
ISSN: 1875-8630
Titre abrégé: Dis Markers
Pays: United States
ID NLM: 8604127
Informations de publication
Date de publication:
2021
2021
Historique:
received:
22
01
2021
revised:
13
05
2021
accepted:
05
06
2021
entrez:
9
8
2021
pubmed:
10
8
2021
medline:
17
8
2021
Statut:
epublish
Résumé
An excess formation of neutrophil extracellular traps (NETs), previously shown to be strongly associated with cytokine storm and acute respiratory distress syndrome (ARDS) with prevalent endothelial dysfunction and thrombosis, has been postulated to be a central factor influencing the pathophysiology and clinical presentation of severe COVID-19. A growing number of serological and morphological evidence has added to this assumption, also in regard to potential treatment options. In this study, we used immunohistochemistry and histochemistry to trace NETs and their molecular markers in autopsy lung tissue from seven COVID-19 patients. Quantification of key immunomorphological features enabled comparison with non-COVID-19 diffuse alveolar damage. Our results strengthen and extend recent findings, confirming that NETs are abundantly present in seriously damaged COVID-19 lung tissue, especially in association with microthrombi of the alveolar capillaries. In addition, we provide evidence that low-density neutrophils (LDNs), which are especially prone to NETosis, contribute substantially to COVID-19-associated lung damage in general and vascular blockages in particular.
Identifiants
pubmed: 34367376
doi: 10.1155/2021/5566826
pmc: PMC8337148
doi:
Substances chimiques
Antigens, CD
0
CEACAM8 protein, human
0
Cell Adhesion Molecules
0
GPI-Linked Proteins
0
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
5566826Informations de copyright
Copyright © 2021 Astrid Obermayer et al.
Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interest regarding the publication of this article.
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