Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
04
07
2021
received:
16
03
2021
accepted:
01
08
2021
pubmed:
10
8
2021
medline:
15
12
2021
entrez:
9
8
2021
Statut:
ppublish
Résumé
Pain is a under-recognized association of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by 17 of 33 (52%) with CASPR2- versus 20 of 108 (19%) with LGI1 antibodies (p = 0.0005), and identified as neuropathic in 89% versus 58% of these, respectively. Typically, in both cohorts, normal nerve conduction studies and reduced intraepidermal nerve fiber densities were observed in the sampled patient subsets. In LGI1 antibody patients, pain responded to immunotherapy (p = 0.008), often rapidly, with greater residual patient-rated impairment observed in CASPR2 antibody patients (p = 0.019). Serum CASPR2 antibodies, but not LGI1 antibodies, bound in vitro to unmyelinated human sensory neurons and rodent dorsal root ganglia, suggesting pathophysiological differences that may underlie our clinical observations. ANN NEUROL 2021;90:683-690.
Identifiants
pubmed: 34370313
doi: 10.1002/ana.26189
pmc: PMC8581990
doi:
Substances chimiques
Autoantibodies
0
CNTNAP1 protein, human
0
CNTNAP2 protein, human
0
Cell Adhesion Molecules, Neuronal
0
Intracellular Signaling Peptides and Proteins
0
Membrane Proteins
0
Nerve Tissue Proteins
0
Potassium Channels, Voltage-Gated
0
anti-leucine-rich glioma-inactivated 1 autoantibody
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-690Subventions
Organisme : British Medical Association Vera Down grant (2013) and Margaret Temple (2017)
Organisme : Wellcome Trust
ID : 104079/Z/14/Z
Pays : United Kingdom
Organisme : Epilepsy Research UK
ID : P1201
Organisme : Medical Research Council
ID : MR/V007173/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02394X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V003534/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Annals of Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.
Références
Eur J Neurol. 2010 Jul;17(7):903-12, e44-9
pubmed: 20642627
Brain. 2018 Aug 1;141(8):2263-2271
pubmed: 29788256
Ann Neurol. 2011 May;69(5):892-900
pubmed: 21416487
Cell. 2018 Aug 9;174(4):999-1014.e22
pubmed: 30096314
J Neurol Neurosurg Psychiatry. 2020 Feb;91(2):177-188
pubmed: 30224548
Neurol Neuroimmunol Neuroinflamm. 2020 Dec 3;8(1):
pubmed: 33272955
Pain. 2008 Jun;136(3):380-387
pubmed: 17888574
Muscle Nerve. 2017 Apr;55(4):520-525
pubmed: 27511450
Brain. 2010 Sep;133(9):2734-48
pubmed: 20663977
Brain. 2018 Feb 1;141(2):348-356
pubmed: 29272336
Ann Neurol. 2017 Jul;82(1):79-92
pubmed: 28628235
Brain. 2017 Apr 1;140(4):898-913
pubmed: 28334857
JAMA Neurol. 2018 Dec 1;75(12):1519-1527
pubmed: 30242309
Brain. 2020 Jun 1;143(6):1731-1745
pubmed: 32437528
J Neurol. 2021 May;268(5):1689-1707
pubmed: 31655889
Neuron. 2018 Feb 21;97(4):806-822.e10
pubmed: 29429934
Neurology. 2015 Dec 8;85(23):2076-8
pubmed: 26400578
J Neurol Neurosurg Psychiatry. 2017 Apr;88(4):353-361
pubmed: 28115470
Ann Neurol. 2012 Aug;72(2):241-55
pubmed: 22473710
Neurology. 2012 Sep 11;79(11):1136-44
pubmed: 22895588