Cardiac Myoediting Attenuates Cardiac Abnormalities in Human and Mouse Models of Duchenne Muscular Dystrophy.

Animals CRISPR-Cas Systems Cardiomyopathies / etiology Cell Line Cells, Cultured Dependovirus / genetics Dystrophin / genetics Gene Editing / methods Genetic Therapy / methods Humans Induced Pluripotent Stem Cells / cytology Male Mice Mice, Inbred C57BL Muscular Dystrophy, Duchenne / complications Myocytes, Cardiac / cytology Transcriptome

Journal

Circulation research
ISSN: 1524-4571
Titre abrégé: Circ Res
Pays: United States
ID NLM: 0047103

Informations de publication

Date de publication:
03 09 2021
Historique:
pubmed: 11 8 2021
medline: 11 1 2022
entrez: 10 8 2021
Statut: ppublish

Résumé

[Figure: see text].

Identifiants

DOI: 10.1161/CIRCRESAHA.121.319579 PMID: 34372664 PMC: PMC8416801
pubmed: 34372664
doi: 10.1161/CIRCRESAHA.121.319579
pmc: PMC8416801
mid: NIHMS1731745
doi:

Substances chimiques

Dmd protein, mouse 0
Dystrophin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

602-616

Subventions

Organisme : NHLBI NIH HHS
ID : K99 HL153683
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138426
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130253
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL153683
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR067294
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD087351
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD087351
Pays : United States

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Auteurs

Ayhan Atmanli (A)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0001-6951-8893

Andreas C Chai (AC)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0001-8651-0164

Miao Cui (M)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.

Zhaoning Wang (Z)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.

Takahiko Nishiyama (T)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.

Rhonda Bassel-Duby (R)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.

Eric N Olson (EN)

Department of Molecular Biology (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Hamon Center for Regenerative Science and Medicine (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Center (A.A., A.C.C., M.C., Z.W., T.N., R.B.-D., E.N.O.), University of Texas Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0003-1151-8262

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Systèmes CRISPR-Cas › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Cellules › Cellules cultivées › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Virus › Virus à ADN › Parvoviridae › Parvovirinae › Dependovirus › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Dystrophine › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Thérapie génétique › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Dystrophies musculaires › Myopathie de Duchenne › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Cardiac Myoediting Attenuates Cardiac...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › Cardiac Myoediting Attenuates Cardiac...