Multifactorial Role of Mitochondria in Echinocandin Tolerance Revealed by Transcriptome Analysis of Drug-Tolerant Cells.
Candida glabrata
antifungal drug tolerance
echinocandins
mitochondria
transcriptomics
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
31 08 2021
31 08 2021
Historique:
pubmed:
11
8
2021
medline:
24
12
2021
entrez:
10
8
2021
Statut:
ppublish
Résumé
Fungal infections cause significant mortality and morbidity worldwide, and the limited existing antifungal reservoir is further weakened by the emergence of strains resistant to echinocandins, a first line of antifungal therapy. Candida glabrata is an opportunistic fungal pathogen that rapidly develops mutations in the echinocandin drug target β-1,3-glucan synthase (GS), which are associated with drug resistance and clinical failure. Although echinocandins are considered fungicidal in
Identifiants
pubmed: 34372698
doi: 10.1128/mBio.01959-21
pmc: PMC8406274
doi:
Substances chimiques
Antifungal Agents
0
Echinocandins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0195921Subventions
Organisme : NCI NIH HHS
ID : P30 CA051008
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI109025
Pays : United States
Références
FEBS Lett. 2000 Jun 2;474(2-3):137-40
pubmed: 10838073
Sci Immunol. 2019 Mar 8;4(33):
pubmed: 30850393
Front Oncol. 2012 Jul 03;2:70
pubmed: 22783546
J Biol Chem. 2007 Jun 1;282(22):15946-53
pubmed: 17426021
Bioinformatics. 2015 Feb 1;31(3):445-6
pubmed: 25294921
FEMS Yeast Res. 2014 Nov;14(7):1128-31
pubmed: 25175946
Future Microbiol. 2011 Apr;6(4):441-57
pubmed: 21526945
J Biochem Biophys Methods. 2005 Dec 31;65(2-3):45-80
pubmed: 16297980
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2688-93
pubmed: 19204294
Clin Infect Dis. 2013 Jun;56(12):1724-32
pubmed: 23487382
Chem Biol Interact. 2020 Apr 1;320:109023
pubmed: 32097615
Antimicrob Agents Chemother. 2017 Oct 24;61(11):
pubmed: 28848005
Antimicrob Agents Chemother. 2021 Jan 20;65(2):
pubmed: 33168610
Antimicrob Agents Chemother. 2012 Jun;56(6):3417-9
pubmed: 22391532
Fungal Biol. 2020 May;124(5):427-439
pubmed: 32389305
Bioinformatics. 2014 Apr 1;30(7):923-30
pubmed: 24227677
Apoptosis. 2007 May;12(5):913-22
pubmed: 17453160
Curr Med Mycol. 2019 Jun;5(2):9-15
pubmed: 31321332
Mol Microbiol. 2011 Feb;79(4):968-89
pubmed: 21299651
Cell Microbiol. 2016 Sep;18(9):1228-38
pubmed: 27155139
Methods Mol Biol. 2017;1508:17-65
pubmed: 27837497
Antimicrob Agents Chemother. 2014 Nov;58(11):6627-38
pubmed: 25155595
Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S612-7
pubmed: 26567278
Antimicrob Agents Chemother. 2012 Sep;56(9):4862-9
pubmed: 22751546
Med Mycol. 2009 Nov;47(7):697-706
pubmed: 19888802
Int J Med Microbiol. 2017 Jun;307(4-5):241-248
pubmed: 28412040
Antimicrob Agents Chemother. 2015;59(6):3615-8
pubmed: 25801575
Genome Biol. 2019 Dec 23;20(1):296
pubmed: 31870423
Nat Rev Dis Primers. 2018 May 11;4:18026
pubmed: 29749387
J Fungi (Basel). 2018 Sep 01;4(3):
pubmed: 30200517
Antimicrob Agents Chemother. 2019 Jun 24;63(7):
pubmed: 31061164
Mol Microbiol. 2008 Aug;69(3):603-20
pubmed: 18547390
Med Mycol. 2012 Apr;50(3):333-6
pubmed: 21939347
J Bacteriol. 1971 Jul;107(1):377-81
pubmed: 5563875
Eukaryot Cell. 2011 Nov;10(11):1376-83
pubmed: 21926328
Antioxid Redox Signal. 2014 Jan 10;20(2):372-82
pubmed: 22978713
Antimicrob Agents Chemother. 2005 Aug;49(8):3264-73
pubmed: 16048935
Eukaryot Cell. 2012 Apr;11(4):532-44
pubmed: 22286093
Mol Cell. 2012 Oct 26;48(2):158-67
pubmed: 23102266
Antimicrob Agents Chemother. 2008 Mar;52(3):1144-6
pubmed: 18086838
Rev Soc Bras Med Trop. 2013 Nov-Dec;46(6):752-8
pubmed: 24474018
Rev Iberoam Micol. 2014 Jan-Mar;31(1):67-71
pubmed: 24270068
Antimicrob Agents Chemother. 2013 Jan;57(1):326-32
pubmed: 23114781
Antimicrob Agents Chemother. 2014 Aug;58(8):4690-6
pubmed: 24890592
PLoS One. 2015 Sep 10;10(9):e0136932
pubmed: 26356475
Med Mycol. 2010 Feb;48(1):155-60
pubmed: 19626543
mBio. 2020 Oct 6;11(5):
pubmed: 33024045
BMC Mol Biol. 2012 Jun 29;13:22
pubmed: 22747760
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Mol Biol Cell. 2000 Dec;11(12):4241-57
pubmed: 11102521
Curr Biol. 2018 Jan 8;28(1):15-27.e7
pubmed: 29249661
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Cell. 2019 Jun 13;177(7):1888-1902.e21
pubmed: 31178118
G3 (Bethesda). 2016 Sep 08;6(9):2893-907
pubmed: 27449515
PLoS Genet. 2019 Dec 30;15(12):e1008551
pubmed: 31887136
PLoS Pathog. 2015 Mar 19;11(3):e1004668
pubmed: 25790300
Genome Res. 2017 Mar;27(3):491-499
pubmed: 28100584
Antimicrob Agents Chemother. 2006 Apr;50(4):1384-92
pubmed: 16569856
mBio. 2019 Jun 4;10(3):
pubmed: 31164462
Leukemia. 2010 Apr;24(4):679-86
pubmed: 20130602
PLoS Pathog. 2009 Jan;5(1):e1000268
pubmed: 19148266
mBio. 2021 Jun 29;12(3):e0112821
pubmed: 34061590
PLoS One. 2017 Feb 13;12(2):e0172228
pubmed: 28192489
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9578-83
pubmed: 20457929
Bioinformatics. 2009 Aug 15;25(16):2078-9
pubmed: 19505943
Front Microbiol. 2016 Dec 15;7:1995
pubmed: 28018323
Antimicrob Agents Chemother. 2006 Apr;50(4):1148-55
pubmed: 16569823
mBio. 2019 Feb 26;10(1):
pubmed: 30808701
J Antimicrob Chemother. 2006 Aug;58(2):458-61
pubmed: 16757500