Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring.
Animals
Antidepressive Agents, Second-Generation
/ toxicity
Anxiety
/ chemically induced
Depression
/ chemically induced
Female
Fluoxetine
/ toxicity
Food Preferences
Hindlimb Suspension
Hippocampus
/ drug effects
Learning Disabilities
/ chemically induced
Male
Maze Learning
/ drug effects
Memory Disorders
/ chemically induced
Pregnancy
Prenatal Exposure Delayed Effects
/ psychology
Psychomotor Performance
/ drug effects
Rats
Recognition, Psychology
/ drug effects
Fluoxetine
In utero
Memory impairment
NR(2B)
Offspring
Pregnancy
Remote memory
Retention deficit
Temporal cortex
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
16
03
2021
revised:
05
08
2021
accepted:
06
08
2021
pubmed:
11
8
2021
medline:
8
2
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
Fluoxetine is often prescribed to treat depression during pregnancy. Rodent studies have shown that fluoxetine exposure during early development can induce persistent changes in the emotional behavior of the offspring. However, the effects of prenatal fluoxetine on memory have not been elucidated. This study evaluates the memory of adult male offspring from rat dams orally administered with a clinically relevant dose of 0.7 mg/kg fluoxetine from 9 weeks before pregnancy to 1 week before delivery. Hippocampal-dependent (Morris Water Maze, MWM) and non-hippocampal-dependent (Novel Object Recognition, NOR) memory paradigms were assessed. Anxiety- and depressive-like symptoms were also evaluated using the Open Field Test, Tail Suspension Test and Sucrose Preference Test. Male rats exposed to fluoxetine during gestation displayed NOR memory impairments during adulthood, as well as increased anxiety- and depressive-like symptoms. In the MWM, the offspring of fluoxetine-treated dams did not show learning deficits. However, a retention impairment was found on remote memory, 15 days after the end of training. Molecular analyses showed increased expression of NMDA subunit NR
Identifiants
pubmed: 34375626
pii: S0028-3908(21)00306-3
doi: 10.1016/j.neuropharm.2021.108751
pii:
doi:
Substances chimiques
Antidepressive Agents, Second-Generation
0
Fluoxetine
01K63SUP8D
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108751Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.