Epigenetic age prediction in semen - marker selection and model development.
DNA methylation
amplicon bisulfite sequencing
epigenetic age
epigenetic age estimation
semen
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
10 08 2021
10 08 2021
Historique:
received:
16
03
2021
accepted:
17
07
2021
pubmed:
11
8
2021
medline:
12
1
2022
entrez:
10
8
2021
Statut:
ppublish
Résumé
DNA methylation analysis is becoming increasingly useful in biomedical research and forensic practice. The discovery of differentially methylated sites (DMSs) that continuously change over an individual's lifetime has led to breakthroughs in molecular age estimation. Although semen samples are often used in forensic DNA analysis, previous epigenetic age prediction studies mainly focused on somatic cell types. Here, Infinium MethylationEPIC BeadChip arrays were applied to semen-derived DNA samples, which identified numerous novel DMSs moderately correlated with age. Validation of the ten most age-correlated novel DMSs and three previously known sites in an independent set of semen-derived DNA samples using targeted bisulfite massively parallel sequencing, confirmed age-correlation for nine new and three previously known markers. Prediction modelling revealed the best model for semen, based on 6 CpGs from newly identified genes
Identifiants
pubmed: 34375949
pii: 203399
doi: 10.18632/aging.203399
pmc: PMC8386575
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
19145-19164Références
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