Association of time of first corticosteroid treatment with bronchopulmonary dysplasia in preterm infants.
CHNC
chronic lung disease
dexamethasone
hydrocortisone
prematurity
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
revised:
13
07
2021
received:
31
05
2021
accepted:
31
07
2021
pubmed:
12
8
2021
medline:
15
12
2021
entrez:
11
8
2021
Statut:
ppublish
Résumé
To evaluate the association between the time of first systemic corticosteroid initiation and bronchopulmonary dysplasia (BPD) in preterm infants. A multi-center retrospective cohort study from January 2010 to December 2016 using the Children's Hospitals Neonatal Database and Pediatric Health Information System database was conducted. The study population included preterm infants <32 weeks' gestation treated with systemic corticosteroids after 7 days of age and before 34 weeks' postmenstrual age. Stepwise multivariable logistic regression was used to assess the association between timing of corticosteroid initiation and the development of Grade 2 or 3 BPD as defined by the 2019 Neonatal Research Network criteria. We identified 598 corticosteroid-treated infants (median gestational age 25 weeks, median birth weight 760 g). Of these, 47% (280 of 598) were first treated at 8-21 days, 25% (148 of 598) were first treated at 22-35 days, 14% (86 of 598) were first treated at 36-49 days, and 14% (84 of 598) were first treated at >50 days. Infants first treated at 36-49 days (aOR 2.0, 95% CI 1.1-3.7) and >50 days (aOR 1.9, 95% CI 1.04-3.3) had higher independent odds of developing Grade 2 or 3 BPD when compared to infants treated at 8-21 days after adjusting for birth characteristics, admission characteristics, center, and co-morbidities. Among preterm infants treated with systemic corticosteroids in routine clinical practice, later initiation of treatment was associated with a higher likelihood to develop Grade 2 or 3 BPD when compared to earlier treatment.
Identifiants
pubmed: 34379886
doi: 10.1002/ppul.25610
pmc: PMC8453128
mid: NIHMS1730455
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Glucocorticoids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3283-3292Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK125735
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL136525
Pays : United States
Organisme : NICHD NIH HHS
ID : K23 HD091362
Pays : United States
Informations de copyright
© 2021 Wiley Periodicals LLC.
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