Urinary iodine and thyroglobulin are useful markers in infants suspected of congenital hypothyroidism based on newborn screening.
congenital hypothyroidism
newborn screening
thyroglobulin
urinary iodine
Journal
Journal of pediatric endocrinology & metabolism : JPEM
ISSN: 2191-0251
Titre abrégé: J Pediatr Endocrinol Metab
Pays: Germany
ID NLM: 9508900
Informations de publication
Date de publication:
25 Nov 2021
25 Nov 2021
Historique:
received:
22
03
2021
accepted:
22
07
2021
pubmed:
14
8
2021
medline:
25
2
2022
entrez:
13
8
2021
Statut:
epublish
Résumé
Iodine deficiency and excess both cause thyroid dysfunction. Few data describe the relationship between iodine status and outcomes of congenital hypothyroidism (CH) in iodine-sufficient areas. We investigated urinary iodine (UI) concentration and its relationship with the clinical course of CH. We reviewed and retrospectively analyzed patients with positive newborn screening (NBS) for CH from January 2012 to June 2019 in Japan, obtaining UI and UI-urine creatinine ratio (UI/Cr), serum TSH, free T Forty-eight patients were included. Median UI and UI/Cr were 325 μg/L and 3,930 µg/gCr, respectively. UI was high (≥300 μg/L) in 26 (54%) and low (≤99 μg/L) in 11 (23%). LT4 was administered to 34 patients. Iodine status was not related to the need for treatment. We found a U-shaped relationship between Tg and UI/Cr. Patients with high Tg (≥400 ng/mL) and abnormal UI levels required significantly lower LT4 doses (≤20 µg/day) at three years of age. Even if they showed severe hypothyroidism initially, they did not need subsequent dose increments. Abnormal UI levels with Tg elevation were associated with lower LT4 dose requirements. The evaluation of iodine status and Tg concentrations were considered useful in patients suspected of CH.
Identifiants
pubmed: 34388329
pii: jpem-2021-0205
doi: 10.1515/jpem-2021-0205
doi:
Substances chimiques
Biomarkers
0
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
Thyroglobulin
9010-34-8
Iodine
9679TC07X4
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1411-1418Informations de copyright
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
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