Migration cues interpretation by clathrin-coated structures.
Adhesion
Cell migration
Clathrin-mediated endocytosis
Extracellular cues
Signaling
Trafficking
Journal
Current opinion in cell biology
ISSN: 1879-0410
Titre abrégé: Curr Opin Cell Biol
Pays: England
ID NLM: 8913428
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
26
02
2021
revised:
08
07
2021
accepted:
13
07
2021
pubmed:
15
8
2021
medline:
26
11
2021
entrez:
14
8
2021
Statut:
ppublish
Résumé
Cell migration is oriented by cues from the environment. Such cues are read and interpreted by the cell and translated into a reorganization of the migration machinery to steer migration. Receptors at the cell surface are central to detect these cues. These receptors can be internalized and this plays an important role in the decision-making process leading to choosing a migration direction. Independently of endocytosis, recent findings suggest that regulation of these receptors and translation of the information they carry into a phenotype is facilitated by their clustering at discrete locations of the plasma membrane. Clathrin-coated structures are archetypal clustering assemblies and thus provide the cell with a finely tunable mechanism for controlling receptor availability. In addition, clathrin-coated structures can be regulated by many factors playing a role in cell migration and thus take part in feedback loop mechanisms that are instrumental in defining a migration direction.
Identifiants
pubmed: 34391036
pii: S0955-0674(21)00089-2
doi: 10.1016/j.ceb.2021.07.005
pii:
doi:
Substances chimiques
Clathrin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-105Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement Nothing declared.