Kupffer cell reverse migration into the liver sinusoids mitigates neonatal sepsis and meningitis.

Animals Kupffer Cells / immunology Mice Liver / immunology Cell Movement / immunology Animals, Newborn Neonatal Sepsis / immunology Mice, Inbred C57BL Female Histocompatibility Antigens Class II / immunology Hyaluronan Receptors / metabolism Macrophage Migration-Inhibitory Factors / immunology Antigens, Differentiation, B-Lymphocyte / immunology

Journal

Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624

Informations de publication

Date de publication:
Nov 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

In adults, liver-resident macrophages, or Kupffer cells (KCs), reside in the sinusoids and sterilize circulating blood by capturing rapidly flowing microbes. We developed quantitative intravital imaging of 1-day-old mice combined with transcriptomics, genetic manipulation, and in vivo infection assays to interrogate increased susceptibility of newborns to bloodstream infections. Whereas 1-day-old KCs were better at catching

Identifiants

DOI: 10.1126/sciimmunol.adq9704 PMID: 39485859
pubmed: 39485859
doi: 10.1126/sciimmunol.adq9704
doi:

Substances chimiques

Histocompatibility Antigens Class II 0
invariant chain 0
Hyaluronan Receptors 0
Macrophage Migration-Inhibitory Factors 0
Antigens, Differentiation, B-Lymphocyte 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadq9704

Auteurs

Bruna Araujo David (B)

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
ORCID: 0000-0001-8486-329X

Jawairia Atif (J)

Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
Ajmera Transplant Centre, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 2C4, Canada.
ORCID: 0000-0001-6924-7376

Fernanda Vargas E Silva Castanheira (F)

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.

Tamanna Yasmin (T)

Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario K7L 3N6, Canada.
ORCID: 0000-0003-1891-9579

Adrien Guillot (A)

Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin 13353, Germany.
ORCID: 0000-0002-6002-9986

Yeni Ait Ahmed (Y)

Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin 13353, Germany.
ORCID: 0000-0002-8523-4249

Moritz Peiseler (M)

Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin 13353, Germany.
Berlin Institute of Health (BIH), Berlin 10178, Germany.
ORCID: 0000-0001-6195-3866

Josefien W Hommes (JW)

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
ORCID: 0000-0001-7984-2152

Lilian Salm (L)

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern 3010, Switzerland.
ORCID: 0000-0002-6812-3678

Marie-Anne Brundler (MA)

Department of Pathology and Laboratory Medicine and Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
ORCID: 0000-0002-5323-5765

Bas G J Surewaard (BGJ)

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
ORCID: 0000-0001-6367-3235

Wael Elhenawy (W)

Department of Medical Microbiology & Immunology, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Women and Children's Health Research Institute, University of Alberta, Edmonton, Alberta T6G 1C9, Canada.
Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.
Antimicrobial Resistance, One Health Consortium, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Striving for Pandemic Preparedness, Alberta Research Consortium, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.

Sonya MacParland (S)

Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A1, Canada.
ORCID: 0000-0002-8036-1425

Florent Ginhoux (F)

Singapore Immunology Network (SIgN), Agency for Science, Technology, and Research (A(∗)STAR), Singapore 138648, Singapore.
Gustave Roussy Cancer Campus, Villejuif 94800, France.
ORCID: 0000-0002-2857-7755

Kathy McCoy (K)

Department of Microbiology, Immunology, and Infectious Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
ORCID: 0000-0002-3900-9227

Paul Kubes (P)

Calvin, Phoebe, and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada.
Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario K7L 3N6, Canada.
ORCID: 0000-0002-2835-4244

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Cellules de Küpffer › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Système digestif › Foie › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Sepsis néonatal › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes d'histocompatibilité de classe II › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes de surface › Molécules d'adhérence cellulaire › Récepteurs d'écotaxie des lymphocytes › Antigènes CD44 › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs inhibiteurs de la migration des macrophages › Kupffer cell reverse migration into the liver...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes B › Kupffer cell reverse migration into the liver...