Exploring CSF neurofilament light as a biomarker for MS in clinical practice; a retrospective registry-based study.
Multiple sclerosis
cerebrospinal fluid
neurofilament light protein
prognosis
therapy
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
pubmed:
17
8
2021
medline:
22
4
2022
entrez:
16
8
2021
Statut:
ppublish
Résumé
Neurofilament light (NFL) has been increasingly recognized for prognostic and therapeutic decisions. To validate the utility of cerebrospinal fluid NFL (cNFL) as a biomarker in clinical practice of relapsing-remitting multiple sclerosis (RRMS). RRMS patients ( RRMS with relapse had 4.4 times higher median cNFL concentration (1134 [interquartile range (IQR) 499-2744] ng/L) than those without relapse (264 [125-537] ng/L, cNFL is a robust and reliable biomarker of disease activity, treatment response, and prediction of disability and conversion from RRMS to SPMS. Our data suggest that cNFL should be included in the assessment of patients at MS-onset.
Sections du résumé
BACKGROUND
Neurofilament light (NFL) has been increasingly recognized for prognostic and therapeutic decisions.
OBJECTIVE
To validate the utility of cerebrospinal fluid NFL (cNFL) as a biomarker in clinical practice of relapsing-remitting multiple sclerosis (RRMS).
METHODS
RRMS patients (
RESULTS
RRMS with relapse had 4.4 times higher median cNFL concentration (1134 [interquartile range (IQR) 499-2744] ng/L) than those without relapse (264 [125-537] ng/L,
CONCLUSIONS
cNFL is a robust and reliable biomarker of disease activity, treatment response, and prediction of disability and conversion from RRMS to SPMS. Our data suggest that cNFL should be included in the assessment of patients at MS-onset.
Identifiants
pubmed: 34392718
doi: 10.1177/13524585211039104
pmc: PMC9024026
doi:
Substances chimiques
Biomarkers
0
Neurofilament Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
872-884Références
J Neurochem. 2017 Apr;141(2):296-304
pubmed: 27787906
Mult Scler. 2020 Nov;26(13):1691-1699
pubmed: 31680621
Neurology. 2003 Dec 23;61(12):1720-5
pubmed: 14694036
Neurology. 2003 Feb 25;60(4):640-6
pubmed: 12601106
J Neurol Neurosurg Psychiatry. 1998 Mar;64(3):402-4
pubmed: 9527161
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Mult Scler Relat Disord. 2013 Apr;2(2):65-7
pubmed: 25877624
Neurology. 2004 Nov 9;63(9):1586-90
pubmed: 15534240
Neurology. 2004 Jan 27;62(2):226-33
pubmed: 14745058
Neurology. 2020 Jun 9;94(23):e2457-e2467
pubmed: 32434867
Alzheimers Dement (Amst). 2018 Jul 02;10:448-451
pubmed: 30211292
Mult Scler Relat Disord. 2015 Jul;4(4):329-33
pubmed: 26195051
Neurology. 2017 Nov 28;89(22):2230-2237
pubmed: 29079686
Mult Scler. 2010 Mar;16(3):287-92
pubmed: 20086018
Expert Rev Clin Immunol. 2017 Dec;13(12):1143-1153
pubmed: 29090607
Ann Neurol. 2017 Jun;81(6):857-870
pubmed: 28512753
J Neurol Neurosurg Psychiatry. 2016 Feb;87(2):126-9
pubmed: 25716934
Mult Scler. 2018 Sep;24(10):1301-1307
pubmed: 30066611
Mult Scler Relat Disord. 2020 Nov;46:102463
pubmed: 32862040
Acta Neurol Scand. 2017 Jan;135(1):17-24
pubmed: 27558404
Arch Neurol. 2006 Sep;63(9):1277-80
pubmed: 16966505
Mult Scler. 2014 Jan;20(1):43-50
pubmed: 23702432
Ann Neurol. 2011 Jan;69(1):83-9
pubmed: 21280078
Brain. 2018 Aug 1;141(8):2382-2391
pubmed: 29860296
Eur J Neurol. 2017 May;24(5):703-712
pubmed: 28261960
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
Neurology. 2014 Nov 18;83(21):1945-53
pubmed: 25339208
Acta Neurol Scand. 2015;132(199):11-9
pubmed: 26046553
Mult Scler. 2017 Jan;23(1):62-71
pubmed: 27003946
Amyotroph Lateral Scler Frontotemporal Degener. 2020 Aug;21(5-6):452-458
pubmed: 32558597
PLoS One. 2013 Sep 20;8(9):e75091
pubmed: 24073237
Nat Rev Neurol. 2018 Oct;14(10):577-589
pubmed: 30171200
J Neurochem. 1996 Nov;67(5):2013-8
pubmed: 8863508
Ann Clin Transl Neurol. 2019 May 28;6(6):1081-1089
pubmed: 31211172
J Neuroinflammation. 2018 Jul 18;15(1):209
pubmed: 30021640
Neurology. 1990 Jun;40(6):971-5
pubmed: 2189084
Neurosci Lett. 2019 Apr 17;698:58-63
pubmed: 30599262