Investigation of viscoelastic focusing of particles and cells in a zigzag microchannel.
Magnetophoresis
Particle focusing
Particle separation
Viscoelastic fluid
Journal
Electrophoresis
ISSN: 1522-2683
Titre abrégé: Electrophoresis
Pays: Germany
ID NLM: 8204476
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
revised:
26
07
2021
received:
30
04
2021
accepted:
05
08
2021
pubmed:
17
8
2021
medline:
3
3
2022
entrez:
16
8
2021
Statut:
ppublish
Résumé
Microfluidic particle focusing has been a vital prerequisite step in sample preparation for downstream particle separation, counting, detection, or analysis, and has attracted broad applications in biomedical and chemical areas. Besides all the active and passive focusing methods in Newtonian fluids, particle focusing in viscoelastic fluids has been attracting increasing interest because of its advantages induced by intrinsic fluid property. However, to achieve a well-defined focusing position, there is a need to extend channel lengths when focusing micrometer-sized or sub-microsized particles, which would result in the size increase of the microfluidic devices. This work investigated the sheathless viscoelastic focusing of particles and cells in a zigzag microfluidic channel. Benefit from the zigzag structure of the channel, the channel length and the footprint of the device can be reduced without sacrificing the focusing performance. In this work, the viscoelastic focusing, including the focusing of 10 μm polystyrene particles, 5 μm polystyrene particles, 5 μm magnetic particles, white blood cells (WBCs), red blood cells (RBCs), and cancer cells, were all demonstrated. Moreover, magnetophoretic separation of magnetic and nonmagnetic particles after viscoelastic pre-focusing was shown. This focusing technique has the potential to be used in a range of biomedical applications.
Identifiants
pubmed: 34396540
doi: 10.1002/elps.202100126
doi:
Substances chimiques
Polystyrenes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2230-2237Informations de copyright
© 2021 Wiley-VCH GmbH.
Références
Sackmann, E. K., Fulton, A. L., Beebe, D. J., Nature 2014, 507, 181-189.
Mark, D., Haeberle, S., Roth, G., Von Stetten, F., Zengerle, R., in: Kakaç, S., Kosoy, B., Li, D., Pramuanjaroenkij, A. (Eds.), Microfluidics Based Microsystems: Fundamentals and Applications, Springer, Dordrecht 2010, pp. 305-376.
Song, C., Nguyen, N.-T., Tan, S.-H., Asundi, A. K., Lab Chip 2009, 9, 1178-1184.
Bandara, T., Nguyen, N.-T., Rosengarten, G., Chem. Eng. Sci. 2015, 126, 283-295.
Jiao, Z., Huang, X., Nguyen, N.-T., Abgrall, P., Microfluid. Nanofluid. 2008, 5, 205-214.
Nguyen, N.-T., Schubert, S., Richter, S., Dötzel, W., Sens. Actuators, A 1998, 69, 85-91.
Ota, N., Owa, Y., Kawai, T., Tanaka, Y., J. Chromatogr. A 2016, 1455, 172-177.
Gañán-Calvo, A., Montanero, J., Martín-Banderas, L., Flores-Mosquera, M., Adv. Drug Delivery Rev. 2013, 65, 1447-1469.
Jung, W., Han, J., Choi, J.-W., Ahn, C. H., Microelectron. Eng. 2015, 132, 46-57.
Shen, Y., Yalikun, Y., Tanaka, Y., Sens. Actuators, B 2019, 282, 268-281.
Whitesides, G. M., Nature 2006, 442, 368-373.
Yuan, D., Zhang, J., Yan, S., Pan, C., Alici, G., Nguyen, N.-T., Li, W., Biomicrofluidics 2015, 9, 044108.
Yuan, D., Tan, S. H., Zhao, Q., Yan, S., Sluyter, R., Nguyen, N.-T., Zhang, J., Li, W., RSC Adv. 2017, 7, 3461-3469.
Bhagat, A. A. S., Kuntaegowdanahalli, S. S., Kaval, N., Seliskar, C. J., Papautsky, I., Biomed. Microdevices 2010, 12, 187-195.
Nitta, N., Sugimura, T., Isozaki, A., Mikami, H., Hiraki, K., Sakuma, S., Iino, T., Arai, F., Endo, T., Fujiwaki, Y., Cell 2018, 175, 266-276. e213.
Yuan, D., Zhang, J., Sluyter, R., Zhao, Q., Yan, S., Alici, G., Li, W., Lab Chip 2016, 16, 3919-3928.
Nam, J., Shin, Y., Tan, J. K. S., Lim, B. Y., Lim, C. T., Kim, S., Lab Chip 2016, 16, 2086-2092.
Yan, S., Yuan, D., Talanta 2020, 221, 121401.
Isozaki, A., Mikami, H., Tezuka, H., Matsumura, H., Huang, K., Akamine, M., Hiramatsu, K., Iino, T., Ito, T., Karakawa, H., Lab Chip 2020, 20, 2263-2273.
Lei, C., Kobayashi, H., Wu, Y., Li, M., Isozaki, A., Yasumoto, A., Mikami, H., Ito, T., Nitta, N., Sugimura, T., Nat. Protoc. 2018, 13, 1603-1631.
Nitta, N., Iino, T., Isozaki, A., Yamagishi, M., Kitahama, Y., Sakuma, S., Suzuki, Y., Tezuka, H., Oikawa, M., Arai, F., Nat. Commun. 2020, 11, 3452.
Gossett, D. R., Henry, T., Lee, S. A., Ying, Y., Lindgren, A. G., Yang, O. O., Rao, J., Clark, A. T., Di Carlo, D., Proc. Natl. Acad. Sci. USA 2012, 109, 7630-7635.
Henry, T., Gossett, D. R., Moon, Y. S., Masaeli, M., Sohsman, M., Ying, Y., Mislick, K., Adams, R. P., Rao, J., Di Carlo, D., Sci. Transl. Med. 2013, 5, 212ra163.
Zhang, J., Yan, S., Yuan, D., Alici, G., Nguyen, N.-T., Warkiani, M. E., Li, W., Lab Chip 2016, 16, 10-34.
Khoo, B. L., Grenci, G., Lim, Y. B., Lee, S. C., Han, J., Lim, C. T., Nat. Protoc. 2018, 13, 34.
Vaidyanathan, R., Yeo, T., Lim, C. T., Methods Cell Biol. 2018, 147, 151-173.
Kang, Y., Li, D., Kalams, S. A., Eid, J. E., Biomed. Microdevices 2008, 10, 243-249.
Yan, S., Zhang, J., Alici, G., Du, H., Zhu, Y., Li, W., Lab Chip 2014, 14, 2993-3003.
Hejazian, M., Li, W., Nguyen, N.-T., Lab Chip 2015, 15, 959-970.
Zeng, J., Chen, C., Vedantam, P., Brown, V., Tzeng, T.-R. J., Xuan, X., J. Micromech. Microeng. 2012, 22, 105018.
Heyman, J. S., U.S. Patent 5 192 450, 1993.
MacDonald, M., Spalding, G., Dholakia, K., Nature 2003, 426, 421-424.
Augustsson, P., Åberg, L. B., Swärd-Nilsson, A.-M. K., Laurell, T., Microchim. Acta 2009, 164, 269-277.
Yang, S., Ündar, A., Zahn, J. D., Lab Chip 2007, 7, 588-595.
Morton, K. J., Loutherback, K., Inglis, D. W., Tsui, O. K., Sturm, J. C., Chou, S. Y., Austin, R. H., Lab Chip 2008, 8, 1448-1453.
Yamada, M., Nakashima, M., Seki, M., Anal. Chem. 2004, 76, 5465-5471.
Davis, J. A., Inglis, D. W., Morton, K. J., Lawrence, D. A., Huang, L. R., Chou, S. Y., Sturm, J. C., Austin, R. H., Proc. Natl. Acad. Sci. USA 2006, 103, 14779-14784.
Crowley, T. A., Pizziconi, V., Lab Chip 2005, 5, 922-929.
Di Carlo, D., Lab Chip 2009, 9, 3038-3046.
Kuntaegowdanahalli, S. S., Bhagat, A. A. S., Kumar, G., Papautsky, I., Lab Chip 2009, 9, 2973-2980.
Yuan, D., Zhao, Q., Yan, S., Tang, S.-Y., Alici, G., Zhang, J., Li, W., Lab Chip 2018, 18, 551-567.
D'Avino, G., Greco, F., Maffettone, P. L., Annu. Rev. Fluid Mech. 2017, 49, 341-360.
Lu, X., Liu, C., Hu, G., Xuan, X., J. Colloid Interface Sci. 2017, 500, 182-201.
Faridi, M. A., Ramachandraiah, H., Banerjee, I., Ardabili, S., Zelenin, S., Russom, A., J. Nanobiotechnol. 2017, 15, 1-9.
Yuan, D., Zhang, J., Yan, S., Peng, G., Zhao, Q., Alici, G., Du, H., Li, W., Electrophoresis 2016, 37, 2147-2155.
D'Avino, G., Maffettone, P., J. Non-Newtonian Fluid Mech. 2015, 215, 80-104.
Yuan, D., Tan, S. H., Sluyter, R., Zhao, Q., Yan, S., Nguyen, N.-T., Guo, J., Zhang, J., Li, W., Anal. Chem. 2017, 89, 9574-9582.
D'Avino, G., Romeo, G., Villone, M. M., Greco, F., Netti, P. A., Maffettone, P. L., Lab Chip 2012, 12, 1638-1645.
Kang, K., Lee, S. S., Hyun, K., Lee, S. J., Kim, J. M., Nat. Commun. 2013, 4, 2567.
Seo, K. W., Byeon, H. J., Huh, H. K., Lee, S. J., RSC Adv. 2014, 4, 3512-3520.
Leshansky, A., Bransky, A., Korin, N., Dinnar, U., Phys. Rev. Lett. 2007, 98, 234501.
Yang, S., Kim, J. Y., Lee, S. J., Lee, S. S., Kim, J. M., Lab Chip 2011, 11, 266-273.
Xiang, N., Dai, Q., Ni, Z., Appl. Phys. Lett. 2016, 109, 134101.
Liu, C., Guo, J., Tian, F., Yang, N., Yan, F., Ding, Y., Wei, J., Hu, G., Nie, G., Sun, J., ACS Nano 2017, 11, 6968-6976.
Lee, D. J., Brenner, H., Youn, J. R., Song, Y. S., Sci. Rep. 2013, 3, 3258.
Liu, C., Ding, B., Xue, C., Tian, Y., Hu, G., Sun, J., Anal. Chem. 2016, 88, 12547-12553.
Xiang, N., Zhang, X., Dai, Q., Chen, J., Chen, K., Ni, Z., Lab Chip 2016, 16, 2626-2635.
Cha, S., Kang, K., You, J. B., Im, S. G., Kim, Y., Kim, J. M., Rheol. Acta 2014, 53, 927-933.
Yuan, D., Sluyter, R., Zhao, Q., Tang, S., Yan, S., Yun, G., Li, M., Zhang, J., Li, W., Microfluid. Nanofluid. 2019, 23, 41.
Brunn, P., J. Non-Newtonian Fluid Mech. 1980, 7, 271-288.
Asghari, M., Cao, X., Mateescu, B., Van Leeuwen, D., Aslan, M. K., Stavrakis, S., deMello, A. J., ACS Nano 2019, 14, 422-433.
Whitesides, G. M., Ostuni, E., Takayama, S., Jiang, X., Ingber, D. E., Annu. Rev. Biomed. Eng. 2001, 3, 335-373.
Nguyen, N.-T., Wereley, S. T., Shaegh, S. A. M., Fundamentals and Applications of Microfluidics, Artech House, Boston 2019.
Liu, P., Liu, H., Yuan, D., Jang, D., Yan, S., Li, M., Anal. Chem. 2021, 93, 1586-1595.
Tirtaatmadja, V., McKinley, G. H., Cooper-White, J. J., Phys. Fluids 2006, 18, 043101.
Rodd, L. E., Scott, T. P., Boger, D. V., Cooper-White, J. J., McKinley, G. H., J. Non-Newtonian Fluid Mech. 2005, 129, 1-22.
Rodd, L. E., Cooper-White, J. J., Boger, D. V., McKinley, G. H., J. Non-Newtonian Fluid Mech. 2007, 143, 170-191.
Asmolov, E. S., J. Fluid Mech. 1999, 381, 63-87.
Magda, J., Lou, J., Baek, S., DeVries, K., Polymer 1991, 32, 2000-2009.
Pathak, J. A., Ross, D., Migler, K. B., Phys. Fluids 2004, 16, 4028-4034.
Zhu, T., Cheng, R., Liu, Y., He, J., Mao, L., Microfluid. Nanofluid. 2014, 17, 973-982.
Fallahi, H., Yadav, S., Phan, H.-P., Ta, H., Zhang, J., Nguyen, N.-T., Lab Chip 2021, 21, 2008-2018.
Vojtíšek, M., Tarn, M. D., Hirota, N., Pamme, N., Microfluid. Nanofluid. 2012, 13, 625-635.
Ngamsom, B., Esfahani, M. M., Phurimsak, C., Lopez-Martinez, M. J., Raymond, J.-C., Broyer, P., Patel, P., Pamme, N., Anal. Chim. Acta 2016, 918, 69-76.
Kim, M. J., Lee, D. J., Youn, J. R., Song, Y. S., RSC Adv. 2016, 6, 32090-32097.
Del Giudice, F., Madadi, H., Villone, M. M., D'Avino, G., Cusano, A. M., Vecchione, R., Ventre, M., Maffettone, P. L., Netti, P. A., Lab Chip 2015, 15, 1912-1922.
Zhang, J., Yan, S., Yuan, D., Zhao, Q., Tan, S. H., Nguyen, N.-T., Li, W., Lab Chip 2016, 16, 3947-3956.