Linking transport and translation of mRNAs with endosomes and mitochondria.
RNA transport
endosomes
local translation
microtubules
mitochondria
organelle
Journal
EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049
Informations de publication
Date de publication:
05 10 2021
05 10 2021
Historique:
revised:
06
07
2021
received:
12
01
2021
accepted:
27
07
2021
pubmed:
18
8
2021
medline:
25
2
2023
entrez:
17
8
2021
Statut:
ppublish
Résumé
In eukaryotic cells, proteins are targeted to their final subcellular locations with precise timing. A key underlying mechanism is the active transport of cognate mRNAs, which in many systems can be linked intimately to membrane trafficking. A prominent example is the long-distance endosomal transport of mRNAs and their local translation. Here, we describe current highlights of fundamental mechanisms of the underlying transport process as well as of biological functions ranging from endosperm development in plants to fungal pathogenicity and neuronal processes. Translation of endosome-associated mRNAs often occurs at the cytoplasmic surface of endosomes, a process that is needed for membrane-assisted formation of heteromeric protein complexes and for accurate subcellular targeting of proteins. Importantly, endosome-coupled translation of mRNAs encoding mitochondrial proteins, for example, seems to be particularly important for efficient organelle import and for regulating subcellular mitochondrial activity. In essence, these findings reveal a new mechanism of loading newly synthesised proteins onto endocytic membranes enabling intimate crosstalk between organelles. The novel link between endosomes and mitochondria adds an inspiring new level of complexity to trafficking and organelle biology.
Identifiants
pubmed: 34402186
doi: 10.15252/embr.202152445
pmc: PMC8490996
doi:
Substances chimiques
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e52445Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
Références
Biochim Biophys Acta. 2009 Dec;1793(12):1876-85
pubmed: 19895853
Plant Cell. 2018 Oct;30(10):2529-2552
pubmed: 30190374
Science. 2014 Nov 7;346(6210):748-51
pubmed: 25378625
Zygote. 2012 Aug;20(3):237-42
pubmed: 21492502
J Cell Biol. 2015 Dec 7;211(5):945-54
pubmed: 26620910
Cell. 2001 Apr 20;105(2):209-19
pubmed: 11336671
Elife. 2018 Jun 26;7:
pubmed: 29944116
Biol Chem. 2020 May 26;401(6-7):821-833
pubmed: 32229651
Mol Biol Cell. 2011 Oct;22(19):3645-57
pubmed: 21832152
Nat Struct Mol Biol. 2013 Aug;20(8):952-7
pubmed: 23812374
Front Cell Dev Biol. 2019 Nov 26;7:305
pubmed: 31929983
Fungal Genet Biol. 2019 May;126:1-11
pubmed: 30731203
Cell Mol Life Sci. 2021 Mar;78(6):2665-2681
pubmed: 33341920
FEBS Lett. 2002 Feb 20;513(1):77-84
pubmed: 11911884
Plant J. 2012 May;70(3):471-9
pubmed: 22168839
EMBO J. 1998 Aug 17;17(16):4837-47
pubmed: 9707443
RNA. 2015 Aug;21(8):1444-53
pubmed: 26089324
EMBO J. 2000 May 2;19(9):1974-86
pubmed: 10790364
Dev Biol. 1996 Nov 25;180(1):119-30
pubmed: 8948579
Front Mol Biosci. 2019 Nov 22;6:129
pubmed: 31824961
Nat Biotechnol. 1996 Mar;14(3):303-8
pubmed: 9630890
Trends Biochem Sci. 2020 Sep;45(9):764-778
pubmed: 32475683
Dev Cell. 2003 Jul;5(1):161-74
pubmed: 12852860
EMBO J. 2006 Jun 7;25(11):2275-86
pubmed: 16688221
Sci Rep. 2018 Feb 26;8(1):3611
pubmed: 29483520
J Cell Biol. 2001 Apr 16;153(2):307-18
pubmed: 11309412
Cell. 2009 Feb 20;136(4):719-30
pubmed: 19239891
J Cell Sci. 2012 Jun 1;125(Pt 11):2740-52
pubmed: 22357951
Nat Rev Mol Cell Biol. 2021 Jul;22(7):483-504
pubmed: 33837370
Trends Cell Biol. 2019 Jul;29(7):580-590
pubmed: 30929794
Curr Opin Neurobiol. 2019 Aug;57:110-116
pubmed: 30784978
Plant Cell. 2003 Oct;15(10):2265-72
pubmed: 14523246
RNA Biol. 2021 Sep;18(9):1221-1237
pubmed: 33111627
EMBO J. 2011 Aug 31;30(17):3540-52
pubmed: 21878995
Cell Rep. 2016 Apr 19;15(3):540-549
pubmed: 27068463
PLoS Genet. 2009 Sep;5(9):e1000664
pubmed: 19779551
Annu Rev Biochem. 2018 Jun 20;87:351-390
pubmed: 29195049
J Cell Biol. 2014 Mar 17;204(6):989-1007
pubmed: 24637326
Nat Struct Mol Biol. 2012 Mar 18;19(4):441-9
pubmed: 22426546
Mol Cell Biol. 2001 Mar;21(6):2133-43
pubmed: 11238947
Science. 2018 Sep 14;361(6407):1118-1122
pubmed: 30213914
Nat Rev Microbiol. 2017 Jul;15(7):409-421
pubmed: 28479603
Cell. 2008 Sep 5;134(5):843-53
pubmed: 18775316
Nat Methods. 2007 Aug;4(8):633-6
pubmed: 17603490
Nat Struct Mol Biol. 2019 Feb;26(2):110-120
pubmed: 30692646
J Cell Sci. 2006 Dec 1;119(Pt 23):4964-73
pubmed: 17105762
PLoS Genet. 2017 Apr 19;13(4):e1006734
pubmed: 28422978
J Biol Chem. 1974 May 25;249(10):3297-303
pubmed: 4598123
Cell. 2019 Jul 11;178(2):473-490.e26
pubmed: 31230715
Cell. 2012 Feb 17;148(4):752-64
pubmed: 22341447
Trends Cell Biol. 2017 Feb;27(2):141-150
pubmed: 27665063
EMBO Rep. 2014 Jan;15(1):94-102
pubmed: 24355572
EMBO Rep. 2017 Oct;18(10):1786-1800
pubmed: 28827470
Plant J. 2009 Oct;60(1):146-55
pubmed: 19508424
Nat Rev Mol Cell Biol. 2019 May;20(5):267-284
pubmed: 30626975
Trends Cell Biol. 2019 Oct;29(10):791-803
pubmed: 31427208
EMBO J. 2020 Mar 16;39(6):e102513
pubmed: 32073171
Cell Rep. 2019 Jul 30;28(5):1219-1236.e11
pubmed: 31365866
J Cell Sci. 2016 Jul 15;129(14):2778-92
pubmed: 27252385
Nat Struct Mol Biol. 2019 Jul;26(7):557-566
pubmed: 31270476
DNA Repair (Amst). 2004 Jun 3;3(6):671-82
pubmed: 15135734
Science. 2009 Apr 10;324(5924):218-23
pubmed: 19213877
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5049-58
pubmed: 24324176
Curr Opin Microbiol. 2010 Dec;13(6):693-9
pubmed: 20880737
Cell. 2016 May 5;165(4):976-89
pubmed: 27153498
Nat Neurosci. 2016 May;19(5):690-696
pubmed: 27019013
Fungal Genet Biol. 2012 Sep;49(9):675-6
pubmed: 22330672
Autophagy. 2018;14(8):1472-1474
pubmed: 29940787
Science. 2009 Jun 26;324(5935):1729-32
pubmed: 19460965
Neuron. 2018 May 2;98(3):495-511.e6
pubmed: 29656876
J Biol Chem. 2009 May 22;284(21):14572-85
pubmed: 19286658
Annu Rev Microbiol. 2015;69:265-81
pubmed: 26274025
Cell. 2019 Jan 10;176(1-2):73-84.e15
pubmed: 30612742
Nat Struct Mol Biol. 2017 Feb;24(2):152-161
pubmed: 28092367
Science. 2011 Apr 22;332(6028):475-8
pubmed: 21512033
FEMS Microbiol Rev. 2012 Jan;36(1):59-77
pubmed: 21729109
Nat Rev Neurosci. 2021 Feb;22(2):77-91
pubmed: 33288912
Nature. 2018 Sep;561(7722):268-272
pubmed: 30158700
Nat Commun. 2019 Nov 1;10(1):5009
pubmed: 31676752
Science. 2016 Jun 17;352(6292):1430-5
pubmed: 27313041
J Cell Sci. 2001 Feb;114(Pt 3):609-22
pubmed: 11171329
EMBO Rep. 2021 Oct 5;22(10):e52445
pubmed: 34402186
EMBO J. 2009 Jul 8;28(13):1855-66
pubmed: 19494833
Cell Metab. 2015 Jan 6;21(1):95-108
pubmed: 25565208
Trends Biochem Sci. 2020 Aug;45(8):650-667
pubmed: 32409196
Nature. 2019 Jan;565(7739):356-360
pubmed: 30626971
EMBO Rep. 2020 Aug 5;21(8):e48882
pubmed: 32558077
Cell. 2014 Oct 23;159(3):635-46
pubmed: 25307933
Fungal Genet Biol. 2019 May;126:12-16
pubmed: 30738139
J Cell Biol. 2013 Dec 23;203(6):971-84
pubmed: 24368805
Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6877-E6886
pubmed: 27791158
Neuron. 2012 May 10;74(3):453-66
pubmed: 22578497
EMBO J. 2020 May 4;39(9):e102731
pubmed: 32149416
Mol Biol Cell. 2004 Oct;15(10):4669-81
pubmed: 15292452
Annu Rev Biochem. 2019 Jun 20;88:337-364
pubmed: 30508494
Elife. 2018 Jun 26;7:
pubmed: 29944118
Nat Rev Mol Cell Biol. 2015 Feb;16(2):95-109
pubmed: 25549890
Int J Mol Sci. 2021 Apr 22;22(9):
pubmed: 33922020
Discov Med. 2003 Dec;3(19):44-7
pubmed: 20705038
Nat Rev Genet. 2007 Jul;8(7):533-43
pubmed: 17572691
Nat Neurosci. 2021 May;24(5):622-632
pubmed: 33510479
Biochim Biophys Acta. 2014 Nov;1839(11):1062-8
pubmed: 25120199
Mol Cell. 2019 Aug 22;75(4):875-887.e5
pubmed: 31442426
Cell. 2014 Jul 17;158(2):368-382
pubmed: 25036633
Mol Cell. 1998 Oct;2(4):437-45
pubmed: 9809065
Biochim Biophys Acta. 2016 Oct;1863(10):2503-14
pubmed: 27116927
Cell. 2016 Jun 30;166(1):181-92
pubmed: 27321671
Trends Genet. 2002 Dec;18(12):636-42
pubmed: 12446149
J Cell Biol. 2018 Oct 1;217(10):3497-3511
pubmed: 30037924
Nat Commun. 2014 Oct 06;5:5097
pubmed: 25283249
Data Brief. 2020 Apr 11;30:105511
pubmed: 32368581
Cell. 2019 Jan 10;176(1-2):56-72.e15
pubmed: 30612743
Mol Cell Proteomics. 2011 Dec;10(12):M111.011213
pubmed: 21808052
J Neurosci. 2003 Apr 15;23(8):3251-61
pubmed: 12716932
Mol Cell Biol. 2004 Apr;24(7):2637-48
pubmed: 15024055
Science. 2014 Nov 7;346(6210):1257521
pubmed: 25378630
Cell. 2017 Mar 23;169(1):178-178.e1
pubmed: 28340345
Nat Commun. 2014 Dec 09;5:5711
pubmed: 25487825
EMBO Rep. 2019 Jan;20(1):
pubmed: 30552148
EMBO J. 2011 Aug 31;30(17):3481-500
pubmed: 21878991
Protein J. 2019 Jun;38(3):330-342
pubmed: 30868341
PLoS Genet. 2020 Sep 30;16(9):e1008819
pubmed: 32997654
Elife. 2015 May 18;4:
pubmed: 25985087
Mol Microbiol. 2001 Nov;42(4):1047-63
pubmed: 11737646
EMBO Rep. 2019 Sep;20(9):e47381
pubmed: 31338952
J Cell Biol. 2014 Feb 3;204(3):343-57
pubmed: 24493587
PLoS Genet. 2014 Jan;10(1):e1004046
pubmed: 24391515
Plant Physiol. 2020 Jan;182(1):97-109
pubmed: 31611420
Neural Dev. 2015 Feb 25;10:3
pubmed: 25886013
Cell. 2016 May 5;165(4):990-1001
pubmed: 27153499
Semin Cell Dev Biol. 2014 Oct;34:44-54
pubmed: 24882724
Curr Opin Microbiol. 2014 Aug;20:10-8
pubmed: 24835422
Nature. 2001 Dec 6;414(6864):611-6
pubmed: 11740552
Mol Cell Biol. 2010 May;30(9):2105-19
pubmed: 20176811
Elife. 2020 Aug 07;9:
pubmed: 32762840
J Cell Biol. 2017 Feb;216(2):441-461
pubmed: 28100687
Nat Commun. 2017 Sep 19;8(1):583
pubmed: 28928394
Trends Cell Biol. 2016 Sep;26(9):668-679
pubmed: 27289443
PLoS Biol. 2004 Mar;2(3):E79
pubmed: 15024427
Trends Cell Biol. 2019 Feb;29(2):178-188
pubmed: 30455121
EMBO J. 2011 Feb 16;30(4):652-64
pubmed: 21278707
Cell Rep. 2013 Dec 26;5(6):1564-75
pubmed: 24332852
Biol Chem. 2019 May 1;:
pubmed: 31042639
Wiley Interdiscip Rev RNA. 2018 Jan;9(1):
pubmed: 28994236
Plant Cell. 2020 Aug;32(8):2566-2581
pubmed: 32471860
Science. 2009 Nov 27;326(5957):1212-6
pubmed: 19965463
J Biol Chem. 1972 Dec 25;247(24):8043-50
pubmed: 4629740
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13308-13
pubmed: 14583593
Zygote. 2001 Nov;9(4):347-52
pubmed: 11771902
Neuron. 2018 Jul 11;99(1):29-46.e4
pubmed: 30008298
Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):
pubmed: 33771924
Int J Mol Sci. 2020 Nov 18;21(22):
pubmed: 33218218
RNA. 2011 Aug;17(8):1551-65
pubmed: 21705432
EMBO J. 2001 Sep 17;20(18):5091-100
pubmed: 11566874
J Cell Biol. 1994 Aug;126(4):863-76
pubmed: 7914201
Sci Adv. 2020 Mar 13;6(11):eaaz1588
pubmed: 32201729
Neuron. 2001 Aug 2;31(2):261-75
pubmed: 11502257
Science. 2015 Nov 6;350(6261):678-80
pubmed: 26405228
Cell. 2019 Sep 19;179(1):147-164.e20
pubmed: 31539493
Annu Rev Biochem. 2013;82:693-721
pubmed: 23414305