Rare variant

Agricultural Workers' Diseases / genetics Animals Cell Line Genetic Predisposition to Disease Genetic Variation Heterozygote Humans Influenza A Virus, H7N9 Subtype / physiology Influenza A virus / physiology Influenza, Human / genetics Mutation, Missense Myxovirus Resistance Proteins / chemistry Poultry Viral Zoonoses Whole Genome Sequencing

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
20 08 2021
Historique:
received: 20 01 2021
accepted: 19 07 2021
entrez: 20 8 2021
pubmed: 21 8 2021
medline: 28 8 2021
Statut: ppublish

Résumé

Zoonotic avian influenza A virus (IAV) infections are rare. Sustained transmission of these IAVs between humans has not been observed, suggesting a role for host genes. We used whole-genome sequencing to compare avian IAV H7N9 patients with healthy controls and observed a strong association between H7N9 infection and rare, heterozygous single-nucleotide variants in the

Identifiants

DOI: 10.1126/science.abg5953 PMID: 34413236
pubmed: 34413236
pii: 373/6557/918
doi: 10.1126/science.abg5953
doi:

Substances chimiques

MX1 protein, human 0
Myxovirus Resistance Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

918-922

Informations de copyright

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

Auteurs

Yongkun Chen (Y)

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
ORCID: 0000-0001-7811-476X

Laura Graf (L)

Institute of Virology, Medical Center - University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-5890-4147

Tao Chen (T)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
ORCID: 0000-0002-9049-2533

Qijun Liao (Q)

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China.
ORCID: 0000-0001-7517-9867

Tian Bai (T)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
ORCID: 0000-0002-8851-3593

Philipp P Petric (PP)

Institute of Virology, Medical Center - University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Spemann Graduate School of Biology and Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-0882-7240

Wenfei Zhu (W)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Lei Yang (L)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
ORCID: 0000-0002-5239-4617

Jie Dong (J)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
ORCID: 0000-0001-6340-4043

Jian Lu (J)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
ORCID: 0000-0002-9897-5468

Ying Chen (Y)

BGI-Shenzhen, Shenzhen, China.
ORCID: 0000-0001-5013-403X

Juan Shen (J)

BGI-Shenzhen, Shenzhen, China.
ORCID: 0000-0001-8448-9242

Otto Haller (O)

Institute of Virology, Medical Center - University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0003-1202-0909

Peter Staeheli (P)

Institute of Virology, Medical Center - University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0001-7057-6177

Georg Kochs (G)

Institute of Virology, Medical Center - University of Freiburg, Freiburg, Germany.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0003-0187-559X

Dayan Wang (D)

Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China. shuylong@mail.sysu.edu.cn martin.schwemmle@uniklinik-freiburg.de dayanwang@cnic.org.cn.
ORCID: 0000-0002-4990-1016

Martin Schwemmle (M)

Institute of Virology, Medical Center - University of Freiburg, Freiburg, Germany. shuylong@mail.sysu.edu.cn martin.schwemmle@uniklinik-freiburg.de dayanwang@cnic.org.cn.
Faculty of Medicine, University of Freiburg, Freiburg, Germany.
ORCID: 0000-0002-2972-6855

Yuelong Shu (Y)

School of Public Health (Shenzhen), Sun Yat-sen University, Shenzhen, China. shuylong@mail.sysu.edu.cn martin.schwemmle@uniklinik-freiburg.de dayanwang@cnic.org.cn.
Chinese National Influenza Center, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
ORCID: 0000-0001-9279-0916

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Classifications MeSH

questionsmedicales.fr › Maladies professionnelles › Maladies des agriculteurs › Rare variant
questionsmedicales.fr › Eucaryotes › Animaux › Rare variant
questionsmedicales.fr › Cellules › Cellules cultivées › Lignée cellulaire › Rare variant
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Rare variant
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Rare variant
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Rare variant
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Rare variant
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Sous-type H7N9 du virus de la grippe A › Rare variant
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Influenzavirus A › Virus de la grippe A › Rare variant
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Grippe humaine › Rare variant
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation faux-sens › Rare variant
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines de résistance aux myxovirus › Rare variant
questionsmedicales.fr › Aliments et boissons › Aliments › Viande › Volaille › Rare variant
questionsmedicales.fr › Maladies de l'animal › Zoonoses › Zoonoses virales › Rare variant
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Rare variant