Zinc finger proteins of Plasmodium falciparum.
Plasmodium
epigenetic regulator
gene expression
malaria
transcription factor
zinc finger protein
Journal
Cellular microbiology
ISSN: 1462-5822
Titre abrégé: Cell Microbiol
Pays: India
ID NLM: 100883691
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
19
07
2021
received:
29
04
2021
accepted:
24
07
2021
pubmed:
22
8
2021
medline:
14
1
2022
entrez:
21
8
2021
Statut:
ppublish
Résumé
Zinc finger proteins (ZFPs) are a large diverse family of proteins with one or more zinc finger domains in which zinc is important in stabilising the domain. ZFPs can interact with DNA, RNA, lipids or even other proteins and therefore contribute to diverse cellular processes including transcriptional regulation, ubiquitin-mediated protein degradation, mRNA decay and stability. In this review, we provide the first comprehensive classification of ZFPs of the malaria parasite Plasmodium falciparum and provide a state of knowledge on the main ZFPs in the parasite, which include the C2H2, CCCH, RING finger and the PHD finger proteins. TAKE AWAYS: The Plasmodium falciparum genome encodes 170 putative Zinc finger proteins (ZFPs). The C2H2, CCCH, RING finger and PHD finger subfamilies of ZFPs are most represented. Known ZFP functions include the regulation of mRNA metabolism and proteostasis.
Substances chimiques
Proteins
0
DNA
9007-49-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13387Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : NG170/1-1
Organisme : Deutsche Forschungsgemeinschaft
ID : PR905/7-1
Organisme : Deutsche Forschungsgemeinschaft
ID : PR905/20-1
Organisme : Deutscher Akademischer Austauschdienst
ID : PhD scholarship
Informations de copyright
© 2021 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.
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