Access to 1'-Amino Carbocyclic Phosphoramidite to Enable Postsynthetic Functionalization of Oligonucleotides.

Magnetic Resonance Spectroscopy Molecular Structure Oligonucleotides / chemical synthesis Organophosphorus Compounds / chemistry RNA / chemical synthesis

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
03 09 2021
Historique:
pubmed: 24 8 2021
medline: 28 1 2022
entrez: 23 8 2021
Statut: ppublish

Résumé

We report a synthesis of a carbocyclic, abasic RNA phosphoramidite decorated with an amino functionality. The building block was efficiently incorporated into an RNA oligonucleotide in a site-specific manner, followed by deprotection to a free amino group. The amino moiety could be further derivatized as exemplified with fluorescein

Identifiants

DOI: 10.1021/acs.orglett.1c02302 PMID: 34424724
pubmed: 34424724
doi: 10.1021/acs.orglett.1c02302
doi:

Substances chimiques

Oligonucleotides 0
Organophosphorus Compounds 0
phosphoramidite 0
RNA 63231-63-0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

6735-6739

Auteurs

Anna M Rydzik (AM)

Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany.
ORCID: 0000-0003-3158-0493

Regina Balk (R)

Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany.

Martin Koegler (M)

Axolabs GmbH, 95326 Kulmbach, Germany.

Tobias Steinle (T)

Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany.

Doris Riether (D)

Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany.
ORCID: 0000-0002-8535-2501

Dirk Gottschling (D)

Boehringer Ingelheim Pharma GmbH & Co. KG, 88400 Biberach an der Riss, Germany.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Access to 1'-Amino Carbocyclic Phosphoramidite...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Access to 1'-Amino Carbocyclic Phosphoramidite...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Polynucléotides › Oligonucléotides › Access to 1'-Amino Carbocyclic Phosphoramidite...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Access to 1'-Amino Carbocyclic Phosphoramidite...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › Access to 1'-Amino Carbocyclic Phosphoramidite...