Right versus left ventricular remodeling in heart failure due to chronic volume overload.
Animals
Cell Adhesion Molecules
/ genetics
Extracellular Matrix Proteins
/ genetics
Heart Failure
/ metabolism
Heart Ventricles
/ metabolism
Male
Myocardium
/ metabolism
Protein Glutamine gamma Glutamyltransferase 2
Proteome
/ genetics
Pyruvate Kinase
/ genetics
Rats
Rats, Sprague-Dawley
Stroke Volume
Ventricular Remodeling
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 08 2021
24 08 2021
Historique:
received:
06
04
2021
accepted:
10
08
2021
entrez:
25
8
2021
pubmed:
26
8
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Mechanisms of right ventricular (RV) dysfunction in heart failure (HF) are poorly understood. RV response to volume overload (VO), a common contributing factor to HF, is rarely studied. The goal was to identify interventricular differences in response to chronic VO. Rats underwent aorto-caval fistula (ACF)/sham operation to induce VO. After 24 weeks, RV and left ventricular (LV) functions, gene expression and proteomics were studied. ACF led to biventricular dilatation, systolic dysfunction and hypertrophy affecting relatively more RV. Increased RV afterload contributed to larger RV stroke work increment compared to LV. Both ACF ventricles displayed upregulation of genes of myocardial stress and metabolism. Most proteins reacted to VO in a similar direction in both ventricles, yet the expression changes were more pronounced in RV (p
Identifiants
pubmed: 34429479
doi: 10.1038/s41598-021-96618-8
pii: 10.1038/s41598-021-96618-8
pmc: PMC8384875
doi:
Substances chimiques
Cell Adhesion Molecules
0
Extracellular Matrix Proteins
0
Proteome
0
Tgm2 protein, rat
0
Protein Glutamine gamma Glutamyltransferase 2
EC 2.3.2.13
Pkm protein, rat
EC 2.7.1.40
Pyruvate Kinase
EC 2.7.1.40
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17136Informations de copyright
© 2021. The Author(s).
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