Cholera Toxin as a Probe for Membrane Biology.

Cell Membrane / metabolism Cholera Toxin / metabolism Clathrin / metabolism Endocytosis Receptors, Cell Surface / metabolism
GL-Lect hypothesis GM1 cholera toxin B-subunit endocytosis glycolipids membrane curvature membrane nanodomains membrane rafts retrograde trafficking

Journal

Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765

Informations de publication

Date de publication:
03 08 2021
Historique:
received: 20 06 2021
revised: 23 07 2021
accepted: 29 07 2021
entrez: 26 8 2021
pubmed: 27 8 2021
medline: 27 1 2022
Statut: epublish

Résumé

Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in membrane biology and biophysics. CTxB is a homopentameric stable protein that binds tightly to up to five GM1 glycosphingolipids. This provides a robust and tractable model for exploring membrane structure and its dynamics including vesicular trafficking and nanodomain assembly. Here, we review important advances in these fields enabled by use of CTxB and its lipid receptor GM1.

Identifiants

DOI: 10.3390/toxins13080543 PMID: 34437414 PMC: PMC8402489
pubmed: 34437414
pii: toxins13080543
doi: 10.3390/toxins13080543
pmc: PMC8402489
pii:
doi:

Substances chimiques

Clathrin 0
Receptors, Cell Surface 0
ganglioside receptor 0
Cholera Toxin 9012-63-9

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM106720
Pays : United States
Organisme : NIH HHS
ID : R01 GM106720
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NIH HHS
ID : R37 DK048106
Pays : United States
Organisme : NIH HHS
ID : P30 DK034854
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK104868
Pays : United States
Organisme : NIDDK NIH HHS
ID : R37 DK048106
Pays : United States
Organisme : NIH HHS
ID : RO1 DK104868
Pays : United States

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Auteurs

Anne K Kenworthy (AK)

Center for Membrane and Cell Physiology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

Stefanie S Schmieder (SS)

Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Harvard Digestive Diseases Center, Boston, MA 02115, USA.

Krishnan Raghunathan (K)

Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA 15224, USA.
ORCID: 0000-0003-2228-6313

Ajit Tiwari (A)

Center for Membrane and Cell Physiology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.
ORCID: 0000-0001-9849-1466

Ting Wang (T)

Center for Membrane and Cell Physiology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA 22903, USA.

Christopher V Kelly (CV)

Department of Physics and Astronomy, Wayne State University, Detroit, MI 48201, USA.
ORCID: 0000-0003-0886-8691

Wayne I Lencer (WI)

Division of Gastroenterology, Boston Children's Hospital, Boston, MA 02115, USA.
Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.
Harvard Digestive Diseases Center, Boston, MA 02115, USA.

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Classifications MeSH

questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Cholera Toxin as a Probe for Membrane Biology.
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Entérotoxines › Toxine cholérique › Cholera Toxin as a Probe for Membrane Biology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines du transport vésiculaire › Clathrine › Cholera Toxin as a Probe for Membrane Biology.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Endocytose › Cholera Toxin as a Probe for Membrane Biology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Cholera Toxin as a Probe for Membrane Biology.