Successful Genetic Screening and Creating Awareness of Familial Hypercholesterolemia and Other Heritable Dyslipidemias in the Netherlands.
cholesterol
dyslipidemia
familial hypercholesterolemia
genetic screening
lipids
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
29 07 2021
29 07 2021
Historique:
received:
20
06
2021
revised:
26
07
2021
accepted:
28
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
8
2
2022
Statut:
epublish
Résumé
The genetic screening program for familial hypercholesterolemia (FH) in the Netherlands, which was embraced by the Dutch Ministry of Health from 1994 to 2014, has led to twenty years of identification of at least 1500 FH cases per year. Although funding by the government was terminated in 2014, the approach had proven its effectiveness and had built the foundation for the development of more sophisticated diagnostic tools, clinical collaborations, and new molecular-based treatments for FH patients. As such, the community was driven to continue the program, insurance companies were convinced to collaborate, and multiple approaches were launched to find new index cases with FH. Additionally, the screening was extended, now also including other heritable dyslipidemias. For this purpose, a diagnostic next-generation sequencing (NGS) panel was developed, which not only comprised the culprit
Identifiants
pubmed: 34440342
pii: genes12081168
doi: 10.3390/genes12081168
pmc: PMC8392502
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Circulation. 2020 Jun 2;141(22):1742-1759
pubmed: 32468833
Eur J Prev Cardiol. 2020 Jul 27;:2047487320942996
pubmed: 32718233
Clin Genet. 1999 Aug;56(2):158-63
pubmed: 10517255
Hum Mutat. 2013 Jan;34(1):83-7
pubmed: 22949395
J Clin Lipidol. 2018 Jan - Feb;12(1):152-161
pubmed: 29169939
N Engl J Med. 2017 Jul 20;377(3):296-297
pubmed: 28723334
Atherosclerosis. 2007 Aug;193(2):445-8
pubmed: 16989838
N Engl J Med. 2014 Jul 3;371(1):32-41
pubmed: 24941082
Eur Heart J. 2013 Apr;34(13):962-71
pubmed: 23416791
J Lipid Res. 2016 Mar;57(3):482-91
pubmed: 26802169
Nat Genet. 1995 May;10(1):28-34
pubmed: 7647785
Am J Cardiol. 2012 Jul 1;110(1):62-6
pubmed: 22464213
Circulation. 2003 Mar 25;107(11):1473-8
pubmed: 12654602
Endocr Rev. 2015 Feb;36(1):131-47
pubmed: 25554923
Science. 2008 Dec 12;322(5908):1702-5
pubmed: 19074352
Eur Heart J. 2014 Aug 21;35(32):2146-57
pubmed: 25053660
Circulation. 2007 Aug 7;116(6):664-8
pubmed: 17664376
Hum Mutat. 2005 Dec;26(6):550-6
pubmed: 16250003
Eur Heart J. 2015 Sep 21;36(36):2425-37
pubmed: 26009596
N Engl J Med. 2017 Jul 20;377(3):211-221
pubmed: 28538136
Drugs Today (Barc). 2016 Mar;52(3):183-92
pubmed: 27186592
J Lipid Res. 2015 Jul;56(7):1296-307
pubmed: 25954050
N Engl J Med. 2006 Mar 23;354(12):1264-72
pubmed: 16554528
N Engl J Med. 2019 Oct 17;381(16):1547-1556
pubmed: 31618540
Nat Genet. 2003 Jun;34(2):154-6
pubmed: 12730697
Front Genet. 2020 Sep 23;11:1020
pubmed: 33173529
Lancet. 2001 Jan 20;357(9251):165-8
pubmed: 11213091
Heart Lung Circ. 2021 Mar;30(3):372-379
pubmed: 32873489
Atherosclerosis. 2015 Aug;241(2):597-606
pubmed: 26115072
J Clin Endocrinol Metab. 2016 May;101(5):2113-21
pubmed: 27014949
J Lipid Res. 2010 Aug;51(8):2058-73
pubmed: 20371550
Curr Opin Lipidol. 2021 Apr 1;32(2):117-122
pubmed: 33395105
JAMA. 2016 Sep 27;316(12):1289-97
pubmed: 27673306
Science. 2016 Mar 11;351(6278):1166-71
pubmed: 26965621
N Engl J Med. 2017 Jan 5;376(1):41-51
pubmed: 27959715
Arterioscler Thromb Vasc Biol. 1997 Jan;17(1):107-13
pubmed: 9012644
N Engl J Med. 2020 Apr 16;382(16):1520-1530
pubmed: 32197277
Curr Opin Lipidol. 2015 Jun;26(3):200-9
pubmed: 25950706
Ann Intern Med. 2008 May 6;148(9):712-4
pubmed: 18458293
N Engl J Med. 2020 Aug 20;383(8):711-720
pubmed: 32813947
Atherosclerosis. 2020 Oct;310:83-87
pubmed: 32927124
Eur Heart J. 2020 Jan 1;41(1):99-109c
pubmed: 31764986
Bol Oficina Sanit Panam. 1968 Oct;65(4):281-393
pubmed: 4234760
J Lipid Res. 2009 Apr;50 Suppl:S172-7
pubmed: 19020338
Clin Chem. 2019 Oct;65(10):1258-1266
pubmed: 31307996
J Am Coll Cardiol. 2019 Feb 5;73(4):477-487
pubmed: 30704580
J Am Coll Cardiol. 2020 May 26;75(20):2553-2566
pubmed: 32439005
Clin Biochem Rev. 2012 Feb;33(1):25-31
pubmed: 22363096
J Clin Lipidol. 2017 Nov - Dec;11(6):1329-1337.e3
pubmed: 28951076
N Engl J Med. 2014 Jul 3;371(1):22-31
pubmed: 24941081
JAMA Cardiol. 2020 Apr 1;5(4):390-399
pubmed: 32049305
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):128-140
pubmed: 33232200
Arterioscler Thromb. 1993 May;13(5):720-8
pubmed: 8485124
N Engl J Med. 2016 Oct 27;375(17):1628-1637
pubmed: 27783906
Atherosclerosis. 2021 Mar;321:14-20
pubmed: 33601267
J Am Coll Cardiol. 2019 Jul 30;74(4):512-522
pubmed: 31345425
Open Cardiovasc Med J. 2017 Sep 14;11:84-93
pubmed: 29204218
Atherosclerosis. 2016 Oct;253:7-14
pubmed: 27573733
Curr Opin Lipidol. 2021 Apr 1;32(2):112-116
pubmed: 33560669
Circulation. 2003 Sep 30;108(13):1537-40
pubmed: 14517148
Lancet Diabetes Endocrinol. 2016 Jul;4(7):577-87
pubmed: 27185354
Atherosclerosis. 1998 Oct;140(2):199-270
pubmed: 9862269
N Engl J Med. 2009 Dec 24;361(26):2518-28
pubmed: 20032323
BMC Med Genomics. 2020 Feb 10;13(1):23
pubmed: 32041611
Int J Mol Sci. 2021 May 30;22(11):
pubmed: 34070931
Circ Genom Precis Med. 2021 Feb;14(1):e003106
pubmed: 33440130
J Clin Lipidol. 2011 May-Jun;5(3):133-140
pubmed: 21600517
Atherosclerosis. 2005 May;180(1):93-9
pubmed: 15823280
J Clin Lipidol. 2020 Mar - Apr;14(2):207-217.e7
pubmed: 32088153
N Engl J Med. 2019 Dec 26;381(26):2584
pubmed: 31881148
Adv Clin Chem. 2011;54:81-107
pubmed: 21874758
Lancet. 2010 Nov 13;376(9753):1670-81
pubmed: 21067804
J Am Coll Cardiol. 2016 Jun 7;67(22):2578-89
pubmed: 27050191
J Am Coll Cardiol. 2014 Aug 5;64(5):485-94
pubmed: 25082583