Whole-Genome Differentially Hydroxymethylated DNA Regions among Twins Discordant for Cardiovascular Death.

Cardiovascular Diseases / genetics Computational Biology DNA Methylation Epigenesis, Genetic Humans Infant, Newborn Infant, Newborn, Diseases / genetics Whole Genome Sequencing / methods
cardiovascular disease dizygotic hydroxymethylation monozygotic twins

Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
29 07 2021
Historique:
received: 10 07 2021
revised: 26 07 2021
accepted: 29 07 2021
entrez: 27 8 2021
pubmed: 28 8 2021
medline: 12 2 2022
Statut: epublish

Résumé

Epigenetics is a mechanism underlying cardiovascular disease. It is unknown whether DNA hydroxymethylation is prospectively associated with the risk for cardiovascular death independent of germline and common environment. Male twin pairs middle-aged in 1969-1973 and discordant for cardiovascular death through December 31, 2014, were included. Hydroxymethylation was quantified in buffy coat DNA collected in 1986-1987. The 1893 differentially hydroxymethylated regions (DhMRs) were identified after controlling for blood leukocyte subtypes and age among 12 monozygotic (MZ) pairs (Benjamini-Hochberg False Discovery Rate < 0.01), of which the 102 DhMRs were confirmed with directionally consistent log

Identifiants

DOI: 10.3390/genes12081183 PMID: 34440357 PMC: PMC8392630
pubmed: 34440357
pii: genes12081183
doi: 10.3390/genes12081183
pmc: PMC8392630
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Twin Study

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : R21 HL127368
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States

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Auteurs

Jun Dai (J)

Department of Public Health, College of Health Sciences, Des Moines University, Des Moines, IA 50312, USA.
ORCID: 0000-0001-7930-2885

Ming Leung (M)

Institute for Personalized Medicine, Penn State College of Medicine, Hershey, PA 17033, USA.

Weihua Guan (W)

Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA.

Han-Tian Guo (HT)

Bioinformatics and Computational Biology Undergraduate Program, Iowa State University, Ames, IA 50011, USA.

Ruth E Krasnow (RE)

Center for Health Sciences, SRI International, Menlo Park, CA 94025, USA.

Thomas J Wang (TJ)

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Wael El-Rifai (W)

Department of Surgery, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Zhongming Zhao (Z)

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
ORCID: 0000-0002-3477-0914

Terry Reed (T)

Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Classifications MeSH

questionsmedicales.fr › Maladies cardiovasculaires › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies néonatales › Whole-Genome Differentially Hydroxymethylated...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ADN › Séquençage du génome entier › Whole-Genome Differentially Hydroxymethylated...