Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol.
Aged
Aged, 80 and over
Alcohol Drinking
/ urine
Anthropometry
Biomarkers
/ blood
Cardiovascular Diseases
/ prevention & control
Cholesterol
/ blood
Cholesterol, LDL
/ blood
Cross-Sectional Studies
Female
Heart Disease Risk Factors
Humans
Middle Aged
Randomized Controlled Trials as Topic
Tartrates
/ urine
Wine
Mediterranean diet
PREDIMED
biomarkers
body fat
cardiovascular risk
lipid profile
menopause
polyphenols
tartaric acid
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
22 Aug 2021
22 Aug 2021
Historique:
received:
01
07
2021
revised:
16
08
2021
accepted:
19
08
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
15
9
2021
Statut:
epublish
Résumé
Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60-80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01),
Identifiants
pubmed: 34445043
pii: nu13082883
doi: 10.3390/nu13082883
pmc: PMC8399930
pii:
doi:
Substances chimiques
Biomarkers
0
Cholesterol, LDL
0
Tartrates
0
Cholesterol
97C5T2UQ7J
tartaric acid
W4888I119H
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Interprofesional del vino
ID : PID2020-114022RB-I00
Organisme : Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
ID : AGL2016- 75329-R
Organisme : Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición
Organisme : Instituto de Salud Carlos III
Organisme : Generalitat de Catalunya
ID : 2017SGR 196
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