Insights Into the Oral Microbiome and Barrett's Esophagus Early Detection: A Narrative Review.
Adenocarcinoma
/ diagnosis
Barrett Esophagus
/ diagnosis
Dysbiosis
/ complications
Early Diagnosis
Esophageal Mucosa
/ microbiology
Esophageal Neoplasms
/ diagnosis
Humans
Microbiota
Mouth Mucosa
/ microbiology
RNA, Ribosomal, 16S
/ genetics
Sequence Analysis, RNA
Streptococcus
/ isolation & purification
Journal
Clinical and translational gastroenterology
ISSN: 2155-384X
Titre abrégé: Clin Transl Gastroenterol
Pays: United States
ID NLM: 101532142
Informations de publication
Date de publication:
26 08 2021
26 08 2021
Historique:
received:
12
01
2021
accepted:
09
07
2021
entrez:
27
8
2021
pubmed:
28
8
2021
medline:
1
2
2022
Statut:
epublish
Résumé
Barrett's esophagus (BE) prevalence has increased steadily over the past several decades and continues to be the only known precursor of esophageal adenocarcinoma. The exact cause of BE is still unknown. Most evidence has linked BE to gastroesophageal reflux disease, which injures squamous esophageal mucosa and can result in the development of columnar epithelium with intestinal metaplasia. However, this relationship is inconsistent-not all patients with severe gastroesophageal reflux disease develop BE. There is increasing evidence that the host microbiome spanning the oral and esophageal environments differs in patients with and without BE. Several studies have documented the oral and esophageal microbiome's composition for BE with inconsistent findings. The scarcity and inconsistency of the literature and the dynamic phenomena of microbiota all warrant further studies to validate the findings and dissect the effects of oral microbiota, which are considered a viable proxy to represent esophageal microbiota by many researchers. This review aims to summarize the variability of the oral and esophageal microbiome in BE by using the example of Streptococcus to discuss the limitations of the current studies and suggest future directions. Further characterization of the sensitivity and specificity of the oral microbiome as a potential risk prediction or prevention marker of BE is critical, which will help develop noninvasive early detection methods for BE, esophageal adenocarcinoma, and other esophageal diseases.
Identifiants
pubmed: 34446641
doi: 10.14309/ctg.0000000000000390
pii: 01720094-202109000-00001
pmc: PMC8397287
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e00390Informations de copyright
Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.
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