Context dependent differences in working memory related brain activity in heavy cannabis users.
Cannabis
Cognitive control
Context
Working memory
fMRI
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
23
03
2021
accepted:
03
08
2021
pubmed:
28
8
2021
medline:
19
5
2022
entrez:
27
8
2021
Statut:
ppublish
Résumé
Compromised cognitive control in cannabis use-tempting situations is thought to play a key role in the development of cannabis use disorders. However, little is known about how exposure to cannabis cues and contexts may influence cognitive control and the underlying neural mechanisms in cannabis users. Working memory (WM) is an attention reliant executive function central to cognitive control. In this study, we investigated how distracting cannabis words affected WM load-dependent performance and related brain activity in near-daily cannabis users (N = 36) relative to controls (N = 33). Brain activity was recorded during a novel N-back flanker WM task with neutral and cannabis flankers added as task-irrelevant distractors. On a behavioural level, WM performance did not differ between groups, and the presence of cannabis flankers did not affect performance. However, in cannabis users compared to controls, the presence of cannabis flankers reduced WM load-related activity in multiple regions, including the insula, thalamus, superior parietal lobe and supramarginal gyrus. The group specificity of these effects suggest that cannabis users might differ from controls in the way they process cannabis-related cues and that cannabis cue exposure could interfere with other cognitive processes under cognitively demanding circumstances. Future studies should focus on the role of context in cognitive control-related processes like WM and attention to further elucidate potential cognitive impairments in heavy cannabis users and how these relate to loss of control over drug seeking itself.
Identifiants
pubmed: 34448889
doi: 10.1007/s00213-021-05956-y
pii: 10.1007/s00213-021-05956-y
pmc: PMC9110519
doi:
Substances chimiques
Cannabinoid Receptor Agonists
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1373-1385Subventions
Organisme : NIDA NIH HHS
ID : R01 DA042490
Pays : United States
Informations de copyright
© 2021. The Author(s).
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