Recent advances in biocatalysis of nitrogen-containing heterocycles.

Biocatalysis Nitrogen
Biocatalysis Bioretrosynthesis Green chemistry Nitrogen-containing heterocycles Synthetic biology

Journal

Biotechnology advances
ISSN: 1873-1899
Titre abrégé: Biotechnol Adv
Pays: England
ID NLM: 8403708

Informations de publication

Date de publication:
Historique:
received: 07 06 2021
revised: 27 07 2021
accepted: 08 08 2021
pubmed: 28 8 2021
medline: 22 3 2022
entrez: 27 8 2021
Statut: ppublish

Résumé

Nitrogen-containing heterocycles (N-heterocycles) are ubiquitous in both organisms and pharmaceutical products. Biocatalysts are providing green approaches for synthesizing various N-heterocycles under mild reaction conditions. This review summarizes the recent advances in the biocatalysis of N-heterocycles through the discovery and engineering of natural N-heterocycle synthetic pathway, and the design of artificial synthetic routes, with an emphasis on biocatalysts applied in retrosynthetic design for preparing complex N-heterocycles. Furthermore, this review discusses the future prospects and challenges of biocatalysts involved in the synthesis of N-heterocycles.

Identifiants

DOI: 10.1016/j.biotechadv.2021.107813 PMID: 34450199
pubmed: 34450199
pii: S0734-9750(21)00119-1
doi: 10.1016/j.biotechadv.2021.107813
pii:
doi:

Substances chimiques

Nitrogen N762921K75

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

107813

Informations de copyright

Copyright © 2021. Published by Elsevier Inc.

Auteurs

Jing Feng (J)

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.

Wen-Chao Geng (WC)

Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Huifeng Jiang (H)

Key Laboratory of Systems Microbial Biotechnology, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.

Bian Wu (B)

CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China.. Electronic address: wub@im.ac.cn.

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Classifications MeSH

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