Effect of resolvin D5 on T cell differentiation and osteoclastogenesis analyzed by lipid mediator profiling in the experimental arthritis.
Animals
Arthritis, Experimental
Arthritis, Rheumatoid
/ physiopathology
Cell Differentiation
Cell Proliferation
Chromatography, High Pressure Liquid
Docosahexaenoic Acids
/ metabolism
Foot
Humans
Inflammation
Mice
Osteogenesis
/ physiology
Tandem Mass Spectrometry
Th17 Cells
/ metabolism
Zymosan
/ pharmacology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 08 2021
27 08 2021
Historique:
received:
10
02
2021
accepted:
04
08
2021
entrez:
28
8
2021
pubmed:
29
8
2021
medline:
9
11
2021
Statut:
epublish
Résumé
Resolvins, are specialized pro-resolving mediators (SPMs) derived from n-3 polyunsaturated fatty acids. They contribute actively to the resolution of inflammation, but little is known concerning their role in chronic inflammation, such as in rheumatoid arthritis (RA). Here, we performed lipid mediator (LM) profiling in tissues from the paws of SKG arthritic mice using lipid chromatography (LC)/mass spectrometry (MS)/MS-based LM metabololipidomics. We found elevated levels of SPMs including resolvin D5 (RvD5) in these tissues. Moreover, RvD5 levels were significantly correlated with arthritis disease activity. From experiments to assess the role of RvD5 in the pathology of RA, we concluded that RvD5 suppressed Th17 cell differentiation and facilitated regulatory T cell differentiation, as well as inhibiting CD4
Identifiants
pubmed: 34453072
doi: 10.1038/s41598-021-96530-1
pii: 10.1038/s41598-021-96530-1
pmc: PMC8397777
doi:
Substances chimiques
resolvin D5
0
Docosahexaenoic Acids
25167-62-8
Zymosan
9010-72-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
17312Informations de copyright
© 2021. The Author(s).
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