Subtype-selective positive modulation of K
CyPPA
ion channel
patch-clamp
small-conductance Ca2+-activated potassium channel
Journal
British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
29
06
2021
received:
04
01
2021
accepted:
29
07
2021
pubmed:
31
8
2021
medline:
14
4
2022
entrez:
30
8
2021
Statut:
ppublish
Résumé
In the activated state of small-conductance Ca Site-directed mutagenesis, patch-clamp recordings and in silico modelling were utilised to explore the structural determinants for the subtype-selective modulation of K Mutating residues in the HA (V420) and HB (K467) helices of K Selectivity of CyPPA among K
Sections du résumé
BACKGROUND AND PURPOSE
In the activated state of small-conductance Ca
EXPERIMENTAL APPROACH
Site-directed mutagenesis, patch-clamp recordings and in silico modelling were utilised to explore the structural determinants for the subtype-selective modulation of K
KEY RESULTS
Mutating residues in the HA (V420) and HB (K467) helices of K
CONCLUSION AND IMPLICATIONS
Selectivity of CyPPA among K
Identifiants
pubmed: 34458981
doi: 10.1111/bph.15676
pmc: PMC8799485
mid: NIHMS1738338
doi:
Substances chimiques
Calmodulin
0
Potassium Channels, Calcium-Activated
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
460-472Subventions
Organisme : NINDS NIH HHS
ID : R33 NS101182
Pays : United States
Informations de copyright
© 2021 The British Pharmacological Society.
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