Gene Ontology representation for transcription factor functions.

Computational Biology / methods Databases, Genetic / statistics & numerical data Gene Expression Regulation Gene Ontology / statistics & numerical data Molecular Sequence Annotation / statistics & numerical data Transcription Factors / classification
Biocuration Biological databases Gene Ontology Transcription

Journal

Biochimica et biophysica acta. Gene regulatory mechanisms
ISSN: 1876-4320
Titre abrégé: Biochim Biophys Acta Gene Regul Mech
Pays: Netherlands
ID NLM: 101731723

Informations de publication

Date de publication:
Historique:
received: 06 01 2021
revised: 24 08 2021
accepted: 25 08 2021
pubmed: 31 8 2021
medline: 31 12 2021
entrez: 30 8 2021
Statut: ppublish

Résumé

Transcription plays a central role in defining the identity and functionalities of cells, as well as in their responses to changes in the cellular environment. The Gene Ontology (GO) provides a rigorously defined set of concepts that describe the functions of gene products. A GO annotation is a statement about the function of a particular gene product, represented as an association between a gene product and the biological concept a GO term defines. Critically, each GO annotation is based on traceable scientific evidence. Here, we describe the different GO terms that are associated with proteins involved in transcription and its regulation, focusing on the standard of evidence required to support these associations. This article is intended to help users of GO annotations understand how to interpret the annotations and can contribute to the consistency of GO annotations. We distinguish between three classes of activities involved in transcription or directly regulating it - general transcription factors, DNA-binding transcription factors, and transcription co-regulators.

Identifiants

DOI: 10.1016/j.bbagrm.2021.194752 PMID: 34461313
pubmed: 34461313
pii: S1874-9399(21)00070-5
doi: 10.1016/j.bbagrm.2021.194752
pii:
doi:

Substances chimiques

Transcription Factors 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

194752

Informations de copyright

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Auteurs

Pascale Gaudet (P)

Swiss-Prot group, SIB Swiss Institute of Bioinformatics, 1 Rue Michel-Servet, 1211 Genève, Switzerland. Electronic address: pascale.gaudet@sib.swiss.

Colin Logie (C)

Molecular Biology Department, Faculty of Science, Radboud University, PO box 9101, 6500HB Nijmegen, the Netherlands.

Ruth C Lovering (RC)

Functional Gene Annotation, Preclinical and Fundamental Science, UCL Institute of Cardiovascular Science, University College London, London, UK.

Martin Kuiper (M)

Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway.

Astrid Lægreid (A)

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Paul D Thomas (PD)

Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.

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Classifications MeSH

questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › Gene Ontology representation for transcription...
questionsmedicales.fr › Sciences de l'information › Mémorisation et recherche des informations › Bases de données comme sujet › Bases de données factuelles › Bases de données génétiques › Gene Ontology representation for transcription...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Gene Ontology representation for transcription...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Vocabulaire contrôlé › Ontologies biologiques › Gene Ontology › Gene Ontology representation for transcription...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Annotation de séquence moléculaire › Gene Ontology representation for transcription...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Gene Ontology representation for transcription...