Novel Small Molecule Growth Inhibitor Affecting Bacterial Outer Membrane Reduces Extraintestinal Pathogenic Escherichia coli (ExPEC) Infection in Avian Model.
Animals
Anti-Bacterial Agents
/ pharmacology
Bacterial Load
/ drug effects
Bacterial Outer Membrane
/ drug effects
Chickens
/ microbiology
Disease Models, Animal
Escherichia coli Infections
/ drug therapy
Extraintestinal Pathogenic Escherichia coli
/ drug effects
Growth Inhibitors
/ pharmacology
Humans
Poultry Diseases
/ drug therapy
Urinary Tract Infections
/ drug therapy
APEC
ExPEC
LPS
Lactobacillus
Lpt system
LptD/E
lipopolysaccharide
oleate
small molecule
Journal
Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614
Informations de publication
Date de publication:
31 10 2021
31 10 2021
Historique:
pubmed:
2
9
2021
medline:
2
2
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
Avian pathogenic Escherichia coli (APEC), a subgroup of extraintestinal pathogenic E. coli (ExPEC), causes colibacillosis in chickens and is reportedly implicated in urinary tract infections and meningitis in humans. A major limitation for the current ExPEC antibiotic therapy is the development of resistance, and antibacterial drugs that can circumvent this problem are critically needed. Here, we evaluated eight novel membrane-affecting anti-APEC small molecule growth inhibitors (GIs), identified in our previous study, against APEC infection in chickens. Among the GIs tested, GI-7 (the most effective), when administered orally (1 mg/kg of body weight), reduced the mortality (41.7%), severity of lesions (62.9%), and APEC load (2.6 log) in chickens. Furthermore, GI-7 administration at an optimized dose (60 mg/liter) in drinking water also reduced the mortality (14.7%), severity of lesions (29.5%), and APEC load (2.2 log) in chickens. The abundances of
Identifiants
pubmed: 34468186
doi: 10.1128/Spectrum.00006-21
pmc: PMC8557866
doi:
Substances chimiques
Anti-Bacterial Agents
0
Growth Inhibitors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
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