P
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
15 09 2021
15 09 2021
Historique:
pubmed:
3
9
2021
medline:
12
2
2022
entrez:
2
9
2021
Statut:
ppublish
Résumé
An organophosphorus-catalyzed method for the synthesis of unsymmetrical hydrazines by cross-selective intermolecular N-N reductive coupling is reported. This method employs a small ring phosphacycle (phosphetane) catalyst together with hydrosilane as the terminal reductant to drive reductive coupling of nitroarenes and anilines with good chemoselectivity and functional group tolerance. Mechanistic investigations support an autotandem catalytic reaction cascade in which the organophosphorus catalyst drives two sequential and mechanistically distinct reduction events via P
Identifiants
pubmed: 34473484
doi: 10.1021/jacs.1c07272
pmc: PMC8454687
mid: NIHMS1736091
doi:
Substances chimiques
Aniline Compounds
0
Hydrazines
0
Indazoles
0
Nitrobenzenes
0
Organophosphorus Compounds
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
14464-14469Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM114547
Pays : United States
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