The promise of endogenous and exogenous riboflavin in anti-infection.
Antibacterial agent
antifungal agent fmn riboswitch
immune response
mait cell
riboflavin
Journal
Virulence
ISSN: 2150-5608
Titre abrégé: Virulence
Pays: United States
ID NLM: 101531386
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
To resolve the growing problem of drug resistance in the treatment of bacterial and fungal pathogens, specific cellular targets and pathways can be used as targets for new antimicrobial agents. Endogenous riboflavin biosynthesis is a conserved pathway that exists in most bacteria and fungi. In this review, the roles of endogenous and exogenous riboflavin in infectious disease as well as several antibacterial agents, which act as analogues of the riboflavin biosynthesis pathway, are summarized. In addition, the effects of exogenous riboflavin on immune cells, cytokines, and heat shock proteins are described. Moreover, the immune response of endogenous riboflavin metabolites in infectious diseases, recognized by MHC-related protein-1, and then presented to mucosal associated invariant T cells, is highlighted. This information will provide a strategy to identify novel drug targets as well as highlight the possible clinical use of riboflavin.
Identifiants
pubmed: 34490839
doi: 10.1080/21505594.2021.1963909
pmc: PMC8425684
doi:
Substances chimiques
Anti-Infective Agents
0
Cytokines
0
Heat-Shock Proteins
0
Riboflavin
TLM2976OFR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2314-2326Références
Photochem Photobiol. 2007 Jan-Feb;83(1):205-12
pubmed: 16965181
Cell. 2021 Jan 7;184(1):149-168.e17
pubmed: 33278357
J Bacteriol. 2008 Mar;190(5):1546-53
pubmed: 18156273
Mol Microbiol. 2021 Aug;116(2):470-482
pubmed: 33829573
J Immunol. 1997 Jan 15;158(2):905-12
pubmed: 8993010
Curr Eye Res. 2016 Aug;41(8):1050-1056
pubmed: 26644282
Biochem Pharmacol. 2011 Dec 15;82(12):1853-9
pubmed: 21924249
Vox Sang. 2020 Aug;115(6):495-501
pubmed: 32311760
Am J Ophthalmol. 2014 Jul;158(1):64-70.e2
pubmed: 24792103
Tuberculosis (Edinb). 2019 May;116S:S11-S18
pubmed: 31072689
J Org Chem. 2005 Sep 30;70(20):8162-70
pubmed: 16277343
Biophys J. 2006 Aug 15;91(4):1452-9
pubmed: 16751234
Shock. 1999 Jan;11(1):1-12
pubmed: 9921710
PLoS One. 2020 May 29;15(5):e0233947
pubmed: 32470046
Trends Microbiol. 2002;10(10 Suppl):S8-14
pubmed: 12377562
Antibiotics (Basel). 2021 Jan 05;10(1):
pubmed: 33466288
PLoS One. 2015 May 04;10(5):e0126124
pubmed: 25938806
Annu Rev Immunol. 2011;29:139-62
pubmed: 21219181
Ophthalmology. 2014 Jul;121(7):1377-82
pubmed: 24576886
J Fungi (Basel). 2018 Jun 17;4(2):
pubmed: 29914189
Nat Immunol. 2010 Aug;11(8):701-8
pubmed: 20581831
Immunol Cell Biol. 2018 Jul;96(6):630-641
pubmed: 29350807
Microb Cell Fact. 2020 Feb 13;19(1):31
pubmed: 32054466
J Biol Chem. 2015 Dec 18;290(51):30204-11
pubmed: 26468291
Microbiol Mol Biol Rev. 2011 Jun;75(2):321-60
pubmed: 21646432
Curr Opin Immunol. 2017 Jun;46:66-74
pubmed: 28494326
Cell Chem Biol. 2017 May 18;24(5):576-588.e6
pubmed: 28434876
Mediators Inflamm. 2017;2017:9870679
pubmed: 28694566
Keio J Med. 1996 Mar;45(1):48-53
pubmed: 8882468
Transfusion. 2016 Mar;56 Suppl 1:S6-15
pubmed: 27001363
Nucleic Acids Res. 2002 Jul 15;30(14):3141-51
pubmed: 12136096
Sci Adv. 2020 Feb 19;6(8):eaaz0374
pubmed: 32128419
Life Sci. 2005 Nov 26;78(2):134-9
pubmed: 16112685
J Bacteriol. 2012 Dec;194(24):6818-27
pubmed: 23043000
Transfusion. 2016 Dec;56(12):2948-2952
pubmed: 27805261
Eur J Immunol. 2018 Oct;48(10):1698-1706
pubmed: 30059139
J Bacteriol. 2013 Sep;195(18):4037-45
pubmed: 23836860
Virulence. 2018;9(1):1036-1049
pubmed: 30052132
Nat Rev Microbiol. 2020 Jun;18(6):319-331
pubmed: 32047294
PLoS One. 2010 Feb 25;5(2):e9435
pubmed: 20195542
Nature. 2015 Oct 29;526(7575):672-7
pubmed: 26416753
Anal Biochem. 2005 Mar 1;338(1):124-30
pubmed: 15707942
Eur J Pharmacol. 2004 Jun 16;493(1-3):177-82
pubmed: 15189780
Chem Biol Drug Des. 2010 Apr;75(4):339-47
pubmed: 20148904
Med Mycol. 2021 May 4;59(5):505-509
pubmed: 33336238
Transfusion. 2019 Nov;59(11):3501-3510
pubmed: 31599981
Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22044-9
pubmed: 21135205
J Inherit Metab Dis. 2016 Jul;39(4):545-57
pubmed: 27271694
Acta Ophthalmol. 2014 Nov;92(7):656-61
pubmed: 25493311
Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3950-3
pubmed: 20335618
Front Immunol. 2015 Jul 06;6:344
pubmed: 26217338
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):171-6
pubmed: 26445809
Drug Resist Updat. 2011 Aug-Oct;14(4-5):236-50
pubmed: 21807550
J Biol Chem. 1979 Aug 10;254(15):7295-301
pubmed: 110806
Med Res Rev. 2019 Jul;39(4):1338-1371
pubmed: 30927319
Nat Prod Rep. 2005 Jun;22(3):324-50
pubmed: 16010344
Acta Ophthalmol. 2015 Dec;93(8):689-96
pubmed: 25990098
J Inflamm (Lond). 2016 Nov 28;13:36
pubmed: 27932936
Annu Rev Nutr. 2000;20:153-67
pubmed: 10940330
Nat Commun. 2018 Nov 9;9(1):4706
pubmed: 30413689
Front Cell Infect Microbiol. 2021 Feb 02;10:624839
pubmed: 33604309
J Bacteriol. 2016 Nov 4;198(23):3233-3243
pubmed: 27672192
BMC Biol. 2017 Sep 15;15(1):84
pubmed: 28915805
Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5434-E5443
pubmed: 28630305
Vox Sang. 2016 Oct;111(3):235-241
pubmed: 27281512
Mucosal Immunol. 2017 Jan;10(1):58-68
pubmed: 27143301
J Refract Surg. 2009 Sep;25(9):S799-802
pubmed: 19772254
Immunol Rev. 2016 Jul;272(1):120-38
pubmed: 27319347
Inflamm Res. 2013 Mar;62(3):259-73
pubmed: 23229721
Antimicrob Agents Chemother. 2015 Sep;59(9):5736-46
pubmed: 26169403
Blood. 2013 Feb 14;121(7):1124-35
pubmed: 23243281
J Biol Chem. 2015 May 1;290(18):11293-308
pubmed: 25792735
Photodiagnosis Photodyn Ther. 2020 Dec;32:102002
pubmed: 32916327
J Immunol. 2019 Nov 1;203(9):2415-2424
pubmed: 31570507
J Physiol Pharmacol. 2015 Dec;66(6):793-802
pubmed: 26769828
PLoS Pathog. 2016 Oct 19;12(10):e1005949
pubmed: 27760199
Nat Commun. 2018 Aug 22;9(1):3350
pubmed: 30135490
Ophthalmology. 2020 Feb;127(2):159-166
pubmed: 31619359
J Biol Chem. 1976 Jun 10;251(11):3221-8
pubmed: 6447
Cell Chem Biol. 2017 May 18;24(5):535-537
pubmed: 28525764
J Biol Chem. 2007 Jun 8;282(23):17231-41
pubmed: 17446177
J Immunol. 2015 Jul 15;195(2):587-601
pubmed: 26063000
Food Chem Toxicol. 2010 Jul;48(7):1913-8
pubmed: 20430062
J Enzyme Inhib Med Chem. 2018 Dec;33(1):842-849
pubmed: 29693467
mSphere. 2020 Aug 5;5(4):
pubmed: 32759338
Adv Nutr. 2016 Sep 15;7(5):973-5
pubmed: 27633112
Sci Rep. 2016 Sep 13;6:33200
pubmed: 27620349
RNA Biol. 2009 Apr-Jun;6(2):187-94
pubmed: 19246992
J Am Chem Soc. 2020 Jun 17;142(24):10856-10862
pubmed: 32432858
Eur J Clin Microbiol Infect Dis. 2020 Jul;39(7):1201-1208
pubmed: 32056049
Nature. 2009 Mar 12;458(7235):233-7
pubmed: 19169240
Crit Rev Food Sci Nutr. 2017 Nov 22;57(17):3650-3660
pubmed: 27029320
RNA Biol. 2009 Jul-Aug;6(3):276-80
pubmed: 19333008
Nat Commun. 2016 Jun 23;7:11653
pubmed: 27337592
Science. 2019 Oct 25;366(6464):
pubmed: 31649166
Langmuir. 2020 Jul 21;36(28):8272-8281
pubmed: 32569473
Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):131-9
pubmed: 21245535
J Viral Hepat. 2020 Nov;27(11):1096-1107
pubmed: 32510704
Br J Ophthalmol. 2013 May;97(5):669-71
pubmed: 23355529
PLoS Comput Biol. 2020 Aug 14;16(8):e1007898
pubmed: 32797038
Eur J Pharmacol. 2004 May 25;492(2-3):273-80
pubmed: 15178375
Methods Mol Biol. 2018;1787:19-40
pubmed: 29736707
FEBS J. 2015 Aug;282(16):3230-42
pubmed: 25661987
J Exp Med. 1991 Nov 1;174(5):1209-20
pubmed: 1940799
Lancet Infect Dis. 2017 Dec;17(12):e383-e392
pubmed: 28774698
Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d
pubmed: 21890489
J Glob Antimicrob Resist. 2018 Jun;13:231-236
pubmed: 29408383
Graefes Arch Clin Exp Ophthalmol. 2013 Feb;251(2):521-7
pubmed: 23180236
FEBS J. 2019 Jul;286(13):2522-2535
pubmed: 30927485
Infect Immun. 2014 Jan;82(1):393-404
pubmed: 24191299
RNA Biol. 2011 Jul-Aug;8(4):674-80
pubmed: 21593602
Nucleic Acids Res. 2012 Sep 1;40(17):8662-73
pubmed: 22740651
Crit Rev Eukaryot Gene Expr. 2010;20(2):87-103
pubmed: 21133840
PLoS Pathog. 2015 Aug 21;11(8):e1005072
pubmed: 26295709
Science. 2018 May 18;360(6390):739-742
pubmed: 29773744
Curr Opin Virol. 2013 Oct;3(5):495-500
pubmed: 24016777
Future Med Chem. 2018 Apr 1;10(8):935-959
pubmed: 29629843
J Org Chem. 2009 Aug 7;74(15):5297-303
pubmed: 19545132
Life Sci. 2011 Jan 31;88(5-6):265-71
pubmed: 21115019
Wei Sheng Wu Xue Bao. 2012 Nov 4;52(11):1415-20
pubmed: 23383514
Front Immunol. 2014 Oct 08;5:450
pubmed: 25339949
J Biol Chem. 2005 Dec 2;280(48):39809-17
pubmed: 16204239
Nat Rev Microbiol. 2006 Jan;4(1):36-45
pubmed: 16357859
Nat Biotechnol. 2006 Dec;24(12):1558-64
pubmed: 17160062
Immunity. 2019 Apr 16;50(4):871-891
pubmed: 30995504
Protein Expr Purif. 2013 Oct;91(2):161-8
pubmed: 23954596
Life Sci. 2012 Dec 17;91(25-26):1351-7
pubmed: 23123448
Methods Mol Biol. 2014;1103:165-76
pubmed: 24318894
Virulence. 2017 Aug 18;8(6):797-809
pubmed: 27652896
Cochrane Database Syst Rev. 2020 Jun 17;6:CD013001
pubmed: 32557558
Mucosal Immunol. 2015 Mar;8(2):429-40
pubmed: 25269706