Directed evolution predicts cytochrome b G37V target site modification as probable adaptive mechanism towards the QiI fungicide fenpicoxamid in Zymoseptoria tritici.
Journal
Environmental microbiology
ISSN: 1462-2920
Titre abrégé: Environ Microbiol
Pays: England
ID NLM: 100883692
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
revised:
03
09
2021
received:
14
06
2021
accepted:
04
09
2021
pubmed:
8
9
2021
medline:
9
4
2022
entrez:
7
9
2021
Statut:
ppublish
Résumé
Acquired resistance is a threat to antifungal efficacy in medicine and agriculture. The diversity of possible resistance mechanisms and highly adaptive traits of pathogens make it difficult to predict evolutionary outcomes of treatments. We used directed evolution as an approach to assess the resistance risk to the new fungicide fenpicoxamid in the wheat pathogenic fungus Zymoseptoria tritici. Fenpicoxamid inhibits complex III of the respiratory chain at the ubiquinone reduction site (Qi site) of the mitochondrially encoded cytochrome b, a different site than the widely used strobilurins which inhibit the same complex at the ubiquinol oxidation site (Q
Identifiants
pubmed: 34490974
doi: 10.1111/1462-2920.15760
doi:
Substances chimiques
Fungicides, Industrial
0
Lactones
0
Pyridines
0
Strobilurins
0
UK 2A
0
Cytochromes b
9035-37-4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1117-1132Informations de copyright
© 2021 Society for Applied Microbiology and John Wiley & Sons Ltd.
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