Prevalence of right ventricular dysfunction and impact on all-cause death in hospitalized patients with COVID-19: a systematic review and meta-analysis.

COVID-19 / complications Cause of Death Hospital Mortality Hospitalization / statistics & numerical data Humans Pandemics / statistics & numerical data Prevalence Prognosis Risk Assessment / statistics & numerical data Risk Factors SARS-CoV-2 / pathogenicity Ventricular Dysfunction, Right / epidemiology

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
07 09 2021
Historique:
received: 28 04 2021
accepted: 12 08 2021
entrez: 8 9 2021
pubmed: 9 9 2021
medline: 15 9 2021
Statut: epublish

Résumé

The Coronavirus Disease (COVID-19) pandemic imposed a high burden of morbidity and mortality. In COVID-19, direct lung parenchymal involvement and pulmonary microcirculation dysfunction may entail pulmonary hypertension (PH). PH and direct cardiac injury beget right ventricular dysfunction (RVD) occurrence, which has been frequently reported in COVID-19 patients; however, the prevalence of RVD and its impact on outcomes during COVID-19 are still unclear. This study aims to evaluate the prevalence of RVD and associated outcomes in patients with COVID-19, through a Systematic Review and Meta-Analysis. MEDLINE and EMBASE were systematically searched from inception to 15th July 2021. All studies reporting either the prevalence of RVD in COVID-19 patients or all-cause death according to RVD status were included. The pooled prevalence of RVD and Odds Ratio (OR) for all-cause death according to RVD status were computed and reported. Subgroup analysis and meta-regression were also performed. Among 29 studies (3813 patients) included, pooled prevalence of RVD was 20.4% (95% CI 17.1-24.3%; 95% PI 7.8-43.9%), with a high grade of heterogeneity. No significant differences were found across geographical locations, or according to the risk of bias. Severity of COVID-19 was associated with increased prevalence of RVD at meta-regression. The presence of RVD was found associated with an increased likelihood of all-cause death (OR 3.32, 95% CI 1.94-5.70). RVD was found in 1 out of 5 COVID-19 patients, and was associated with all-cause mortality. RVD may represent one crucial marker for prognostic stratification in COVID-19; further prospective and larger are needed to investigate specific management and therapeutic approach for these patients.

Identifiants

DOI: 10.1038/s41598-021-96955-8 PMID: 34493763 PMC: PMC8423751
pubmed: 34493763
doi: 10.1038/s41598-021-96955-8
pii: 10.1038/s41598-021-96955-8
pmc: PMC8423751
doi:

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

17774

Informations de copyright

© 2021. The Author(s).

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Auteurs

Bernadette Corica (B)

Department of Translational and Precision Medicine, Sapienza - University of Rome, Rome, Italy.

Alberto Maria Marra (AM)

Department of Translational Medical Sciences, "Federico II" University of Naples, Naples, Italy.
Center for Pulmonary Hypertension, Thoraxklinik at Heidelberg University Hospital, Heidelberg, Germany.

Stefania Basili (S)

Department of Translational and Precision Medicine, Sapienza - University of Rome, Rome, Italy.

Roberto Cangemi (R)

Department of Translational and Precision Medicine, Sapienza - University of Rome, Rome, Italy.

Antonio Cittadini (A)

Department of Translational Medical Sciences, "Federico II" University of Naples, Naples, Italy.

Marco Proietti (M)

Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. marco.proietti@unimi.it.
Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri, Via Camaldoli 64, 20138, Milan, Italy. marco.proietti@unimi.it.
Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital, Liverpool, UK. marco.proietti@unimi.it.
ORCID: 0000-0003-1452-2478

Giulio Francesco Romiti (GF)

Department of Translational and Precision Medicine, Sapienza - University of Rome, Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Cause de décès › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Mortalité hospitalière › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Hospitalisation › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Épidémies de maladies › Épidémies › Pandémies › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Diagnostic › Pronostic › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Appréciation des risques › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Prevalence of right ventricular dysfunction...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Dysfonction ventriculaire › Dysfonction ventriculaire droite › Prevalence of right ventricular dysfunction...