Focally administered succinate improves cerebral metabolism in traumatic brain injury patients with mitochondrial dysfunction.
Adult
Brain
/ metabolism
Brain Injuries, Traumatic
/ drug therapy
Energy Metabolism
/ drug effects
Female
Humans
Intracranial Pressure
/ drug effects
Lactic Acid
/ metabolism
Male
Microdialysis
Middle Aged
Mitochondria
/ metabolism
Nuclear Magnetic Resonance, Biomolecular
Pyruvic Acid
/ metabolism
Succinic Acid
/ administration & dosage
Cerebral metabolism
microdialysis
mitochondrial dysfunction
succinate
traumatic brain injury (Human)
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
9
9
2021
medline:
9
2
2022
entrez:
8
9
2021
Statut:
ppublish
Résumé
Following traumatic brain injury (TBI), raised cerebral lactate/pyruvate ratio (LPR) reflects impaired energy metabolism. Raised LPR correlates with poor outcome and mortality following TBI. We prospectively recruited patients with TBI requiring neurocritical care and multimodal monitoring, and utilised a tiered management protocol targeting LPR. We identified patients with persistent raised LPR despite adequate cerebral glucose and oxygen provision, which we clinically classified as cerebral 'mitochondrial dysfunction' (MD). In patients with TBI and MD, we administered disodium 2,3-
Identifiants
pubmed: 34494481
doi: 10.1177/0271678X211042112
pmc: PMC8721534
doi:
Substances chimiques
Lactic Acid
33X04XA5AT
Pyruvic Acid
8558G7RUTR
Succinic Acid
AB6MNQ6J6L
Types de publication
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-55Subventions
Organisme : Medical Research Council
ID : G9439390
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0600986
Pays : United Kingdom
Organisme : Medical Research Council
ID : G1002277
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802251
Pays : United Kingdom
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