NK Cells Lose Their Cytotoxicity Function against Cancer Stem Cell-Rich Radiotherapy-Resistant Breast Cancer Cell Populations.
Animals
Breast Neoplasms
/ immunology
CD24 Antigen
/ immunology
Cell Line
Cell Line, Tumor
Cell Movement
/ immunology
Cell Proliferation
/ radiation effects
Cytotoxicity, Immunologic
/ immunology
Epithelial-Mesenchymal Transition
/ genetics
Female
Gene Expression Regulation, Neoplastic
/ radiation effects
Humans
Hyaluronan Receptors
/ immunology
Killer Cells, Natural
/ immunology
Mice, Inbred BALB C
Mice, Nude
Neoplastic Stem Cells
/ immunology
Radiotherapy
/ methods
Xenograft Model Antitumor Assays
/ methods
NK cells
cancer stem cells
immune escape
radiotherapy-resistance
triple negative breast cancer
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 Sep 2021
06 Sep 2021
Historique:
received:
13
08
2021
revised:
01
09
2021
accepted:
02
09
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Cancer stem cells (CSCs) can be induced from differentiated cancer cells in the tumor microenvironment or in response to treatments and exhibit chemo- and radioresistance, leading to tumor recurrence and metastasis. We previously reported that triple negative breast cancer (TNBC) cells with acquired radioresistance exhibited more aggressive features due to an increased CSC population. Therefore, here, we isolated CSCs from radiotherapy-resistant (RT-R)-TNBC cells and investigated the effects of these CSCs on tumor progression and NK cell-mediated cytotoxicity. Compared to MDA-MB-231 and RT-R-MDA-MB-231 cells, CD24
Identifiants
pubmed: 34502547
pii: ijms22179639
doi: 10.3390/ijms22179639
pmc: PMC8431804
pii:
doi:
Substances chimiques
CD24 Antigen
0
CD44 protein, human
0
Hyaluronan Receptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2018R1A2B6001786
Organisme : National Research Foundation of Korea
ID : 2021R1A2B5B0100144611
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