Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate.
Animals
Cardiotonic Agents
/ administration & dosage
Disease Models, Animal
Hemoglobins
/ metabolism
Hypertension, Pulmonary
/ chemically induced
Hypertrophy, Right Ventricular
/ chemically induced
Hypoxia
/ chemically induced
Inositol Phosphates
/ pharmacology
Male
Monocrotaline
/ administration & dosage
Myocardial Contraction
/ drug effects
Rats
Rats, Wistar
Treatment Outcome
Ventricular Dysfunction, Right
/ chemically induced
Ventricular Function, Right
/ physiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
09 09 2021
09 09 2021
Historique:
received:
29
05
2021
accepted:
19
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Pulmonary hypertension (PH) initially results in compensatory right ventricular (RV) hypertrophy, but eventually in RV failure. This transition is poorly understood, but may be triggered by hypoxia. Measurements of RV oxygen tension (pO
Identifiants
pubmed: 34504231
doi: 10.1038/s41598-021-97470-6
pii: 10.1038/s41598-021-97470-6
pmc: PMC8429755
doi:
Substances chimiques
Cardiotonic Agents
0
Hemoglobins
0
Inositol Phosphates
0
inositol trispyrophosphate
0
Monocrotaline
73077K8HYV
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
18002Informations de copyright
© 2021. The Author(s).
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