An Intradermal Spindle Cell Lipoma on the Plantar Hallux in a Patient With Scleroderma and Ehlers-Danlos Syndrome: A Case Report.
CD34
chromosome deletion
excision
scleroderma
spindle cell lipoma
toe
Journal
The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons
ISSN: 1542-2224
Titre abrégé: J Foot Ankle Surg
Pays: United States
ID NLM: 9308427
Informations de publication
Date de publication:
Historique:
received:
24
01
2020
revised:
19
04
2020
accepted:
11
08
2021
pubmed:
12
9
2021
medline:
12
1
2022
entrez:
11
9
2021
Statut:
ppublish
Résumé
Spindle cell lipoma (SCL) is a rare variant of lipomas, which predominantly occurs in the regions of shoulder and posterior neck but rarely on the toes. Epidemiological studies have demonstrated increased incidence of cancers in patients with scleroderma. A 28-year-old female with scleroderma and Ehlers-Danlos syndrome developed a painful, skin colored, raised, polypoid lesion on the plantar side of the left hallux for several years. The lesion was surgically excised. Pathological evaluation showed intradermal bland spindle cells associated with delicate ropey/refractile collagen bundles with strong and diffuse cytoplasmic expression of CD34 but negative expression of Rb and S-100, which are consistent with SCL. We report a first case of SCL on the plantar hallux in a young female patient with scleroderma and Ehlers-Danlos disease with clinical presentations, histopathology, and treatment to raise awareness of clinicians to this rare variant of lipomas.
Identifiants
pubmed: 34507914
pii: S1067-2516(21)00295-7
doi: 10.1053/j.jfas.2021.08.006
pii:
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
199-201Informations de copyright
Copyright © 2021. Published by Elsevier Inc.